临床专家

高瑛

职称：博士、副研究员、硕士生导师

专长

长期从事肿瘤细胞生物学研究，聚焦于胞内囊泡运输以及胞外囊泡分泌的调控与干预在肿瘤微环境中的作用和机制研究

招生专业：分子医学

Email: gaoying@sysucc.org.cn

个人简介：2020年博士毕业后在本中心做博士后，2024年转聘副研究员。主要研究方向为细胞自噬、囊泡运输或细胞外囊泡生物形成的新机制及对肿瘤发生发展的作用，寻找新的肿瘤生物标志物和潜在靶点。目前以第一作者/通讯作者（含共同）在Cell Res（两篇），Signal Transduct Target Ther，J Extracell Vesicles，Cell Death Differ，Cell Death Dis（两篇），Cancer lett 等国际主流学术期刊发表SCI论文多篇，获得发明专利1项；广东省细胞生物学会理事，主持国家自然科学基金青年项目和面上项目、中国博士后创新人才支持计划等科研项目，作为团队负责人荣获第一届全国博士后创新创业大赛揭榜领题赛优胜奖。

教育背景：

2017/09-2020/07，中山大学，肿瘤防治中心，博士

2013/09-2016/07，中山大学，药学院，硕士

2009/09-2013/07，中国药科大学，学士

代表性论文：

(1)Xiaodan Huang#, Lanqing Huo#, Beibei Xiao#, Yi Ouyang#, Foping Chen, Junyun Li, Xueping Zheng, Denghui Wei, Yuanzhong Wu, Ruhua Zhang, Xinping Cao*, Tiebang Kang* and Ying Gao*. Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer. Cell Death Differ, 2024 Jan;31(1):78-89. (IF: 13.7)

(2)Linxia Qian#, Zhonghan Zhang#, Ruhua Zhang#, Xueping Zheng, Beibei Xiao, Xiaomin Zhang, Yuanzhong Wu, Yang Chen, Xingding Zhang, Penghui Zhou, Qingling Fu*, Tiebang Kang*, Ying Gao*. Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity. Cancer Lett, 2024 Jun 22:597:217081. (IF: 9.1)

(3) Lanqing Huo#, Xiaodan Huang#, Ying Wang#, Yi Ouyang#, Xueping Zheng, Yingyi Ouyang, Xinping Cao, Kai Chen, Denghui Wei, Yuanzhong Wu, Ruhua Zhang, Yujie Lin*, Tiebang Kang*, Ying Gao*. RAB33A Promotes Metastasis via RhoC Accumulation through Non-canonical Autophagy in Cervical Cancer. Cell Death Dis, 2025 Feb, 17(accepted). (IF: 8.1)

(4)Yujie Lin#, Denghui Wei#, Xiaobo He#, Lanqing Huo#, Jingxuan Wang, Xia Zhang, Yuanzhong Wu, Ruhua Zhang, Ying Gao*, Tiebang Kang*. RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release. J Extracell Vesicles, 2024 Jul;13(7):e12494. (IF: 15.5)

(5)Ying Gao#, Xueping Zheng#, Boyang Chang#, Yujie Lin#, Xiaodan Huang#, Wen Wang#, Shirong Ding, Weixiang Zhan, Shang Wang, Beibei Xiao, Lanqing Huo, Youhui Yu, Yilin Chen, Run Gong, Yuanzhong Wu, Ruhua Zhang, Li Zhong, Xin Wang, Qiuyan Chen, Song Gao, Zhengfan Jiang, Denghui Wei*, Tiebang Kang*. Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity. Cell Res, 2022 Dec; 32(12): 1086-1104. (IF: 28.1, Cell Research top articles from the past 3 years)

Research Highlight by Li Yu*. A new route for EV biogenesis. Cell Res, 2023 Feb; 33(2): 87-88. (IF: 28.1)

Commentary and Views by Yaping Han, Jianfei Zheng, Liang Ge*. Activated STING1 rides the Rafeesome. Autophagy, 2023 Aug 6:1-4. (IF: 14.6)

(6)Denghui Wei#, Weixiang Zhan#, Ying Gao#, Liyan Huang, Run Gong, Wen Wang, Ruhua Zhang, Yuanzhong Wu, Song Gao, Tiebang Kang*. RAB31 marks and controls an ESCRT-independent exosome pathway. Cell Res, 2021 Feb;31(2):157-177. (IF: 28.1)

Research Highlight by Candia M. Kenific, Haiying Zhang*, David Lyden*. An exosome pathway without an ESCRT. Cell Res, 2021 Feb;31(2):105-106. (IF: 28.1)

(7)Weixiang Zhan#, Yina Liu#, Ying Gao#, Run Gong, Wen Wang, Ruhua Zhang, Yuanzhong Wu, TiebangKang, Denghui Wei*. RMI2 plays crucial roles in growth and metastasis of lung cancer. Signal Transduct Target Ther, 2020 Sep, 5(1): 188. (IF: 40.8)

(8)Ying Gao#, Yajun Liu#, Liang Hong, Zuolong Yang, Xinran Cai, Xiaoyun Chen, Yuanyuan Fu, Yujie Lin, Weijie Wen, Sitong Li, Xingguo Liu, Heqing Huang, Andreas Vogt, Peiqing Liu*, Xiao-Ming Yin*, Min Li*. Golgi-associated LC3 lipidation requires V-ATPase innoncanonical autophagy. Cell Death Dis, 2016 Aug, 7(8): e2330. (IF: 8.1)

主持的基金：

(1) 国家自然科学基金委员会，面上项目，32370835，新型细胞器Rafeesome介导p62分泌促进肝癌发生发展的作用及其机制，2024-01-01至2027-12-31，50万元，在研，主持

(2) 国家自然科学基金委员会，青年科学基金项目，32100544，自噬外泌体的鉴定及形成机制研究，2022-01-01至2023-12-31，20万元，在研，主持

(3) 中国博士后基金委，中国博士后创新人才支持计划，BX2021394，细胞外囊泡的STING在肿瘤微环境中的功能及形成机制，2021-07至2023-06，63万元，结题，主持

专利：