科研学者

黄旭东

职称：副研究员、硕士生导师

专长

表观调控在消化系统肿瘤发生、进展及药物敏感性中的机制研究

职称：副研究员、硕士生导师

专长：表观调控在消化系统肿瘤发生、进展及药物敏感性中的机制研究

邮箱：huangxd@sysucc.org.cn
通讯地址：广州市东风东路651号2号楼725室

 

简介：

　　黄旭东，副研究员，硕士生导师。2017年毕业于北京协和医学院获得肿瘤学博士学位，随后加入中山大学肿瘤防治中心实验研究部开展博士后研究工作，后被聘为特聘副研究员。2022年7月转聘为中山大学副研究员，硕士生导师。主要从事表观遗传介导的蛋白质及细胞代谢调控在恶性肿瘤发生发展及药物耐受过程中的分子机制研究。近年来以第一/通讯（含共同）作者身份在Nature Genetics、Nature Communications、Journal of Clinical Investigation、Molecular Therapy、Theranostics等学术期刊上发表SCI论文5篇；作为主要参与者发表SCI论文11篇。主持国家自然科学基金面上项目、青年项目、广东省自然科学基金面上项目及中国博士后科学基金面上项目各1项。

 

代表性论文(#第一作者，*通讯作者)

  1. Xudong Huang#; Ling Pan#; Zhixiang Zuo#; Mei Li#; Lingxing Zeng; Rui Li; Ying Ye; Jialiang Zhang; Guandi Wu; Ruihong Bai; Lisha Zhuang; Lusheng Wei; Yanfen Zheng; Jiachun Su; Junge Deng; Shuang Deng; Shaoping Zhang; Shihao Zhu; Xu Che; Chengfeng Wang; Chen Wu; Rufu Chen; Dongxin Lin*; Jian Zheng*. LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling. Nature Communications, 2021, 12 (1): 3830
  2. Jian Zheng#; Xudong Huang#; Wen Tan; Dianke Yu; Zhongli Du; Jiang Chang; Lixuan Wei; Yaling Han; Chengfeng Wang; Xu Che; Yifeng Zhou; Xiaoping Miao; Guoliang Jiang; Xianjun Yu; Xianghong Yang; Guangwen Cao; Chaohui Zuo; Zhaoshen Li; Chunyou Wang; Siu Tim Cheung; Yongfeng Jia; Xiongwei Zheng; Hongbing Shen; Chen Wu*; Dongxin Lin*. Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nature Genetics, 2016, 48 (7): 747-757
  3. Ling Pan#; Xudong Huang#; Ze-Xian Liu#; Ying Ye#; Rui Li; Jialiang Zhang; Guandi Wu; Ruihong Bai; Lisha Zhuang; Lusheng Wei; Mei Li; Yanfen Zheng; Jiachun Su; Junge Deng; Shuang Deng; Lingxing Zeng; Shaoping Zhang; Chen Wu; Xu Che; Chengfeng Wang; Rufu Chen; Dongxin Lin*; Jian Zheng*. Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression. The Journal of clinical investigation, 2021, 131 (22): e148130
  4. Rui Li#; Lingxing Zeng#; Hongzhe Zhao#; Junge Deng#; Ling Pan; Shaoping Zhang; Guandi Wu; Ying Ye; Jialiang Zhang; Jiachun Su; Yanfen Zheng; Shuang Deng; Ruihong Bai; Lisha Zhuang; Mei Li; Zhixiang Zuo; Dongxin Lin*; Jian Zheng*; Xudong Huang*. ATXN2-mediated translation of TNFR1 promotes esophageal squamous cell carcinoma via m6A-dependent manner. Molecular Therapy, 2022, 30 (3): 1089-1103
  5. Xudong Huang#; Jian Zheng#; Jun Li#; Xu Che#; Wenle Tan; Wen Tan; Mingming Shao; Xinxin Cheng; Zhongli Du; Yanjie Zhao; Chengfeng Wang*; Chen Wu*; Dongxin Lin*. Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine. Theranostics, 2018, 8 (12): 3366-3379

 

 

更新时间：2023年1月9日