操隆辉

一、基本情况

2001年中山医科大学本科毕业后一直在中山大学肿瘤防治中心麻醉科工作，2005年获中山大学临床医学硕士学位，2010年获中山大学临床医学博士学位， 2010年赴美国Thomas Jefferson University进修学习，开展与参与多项基础及临床研究，主要从事麻醉药物作用机制及其与恶性肿瘤发生、发展和转移关系以及单肺通气肺损伤的研究。2014年赴美国斯坦福大学疼痛研究中心从事疼痛领域基础研究。在麻醉及外科专业领域高影响力期刊如Ann Surg，Anesth Analg, Anaesth Crit Care Pain Med等以第一或者通讯作者发表SCI论文多篇。

二、代表性研究成果

1. Zhang T, Li H, Lin C, An R, Lin W, Tan H, Cao L*. Effects of an intraoperative intravenous Bolus Dose of Dexmedetomidine on postoperative catheter-related bladder discomfort in male patients undergoing transurethral resection of bladder tumors: a randomized, double-blind, controlled trial. Eur J Clin Pharmacol. 2024 Mar;80(3):465-474.

2. Li X, Peng C, Liu Y, Hu Y, Yang L, Yu Y, Zeng H, Huang W, Li Q, Tao N, Cao L*, Zhou J. Modified American College of Radiology Thyroid Imaging Reporting and Data System and Modified Artificial Intelligence Thyroid Imaging Reporting and Data System for Thyroid Nodules: A Multicenter Retrospective Study. Thyroid. 2024 Jan; 34(1):88-100.

3. Yu J, Wu Z, An R, Li H, Zhang T, Lin W, Tan H, Cao L*. Association between driving pressure and postoperative pulmonary complications in patients undergoing lung resection surgery: A randomised clinical trial. Anaesth Crit Care Pain Med. 2023 Feb;42(1):101160.

4. Gao W, Li H, Li T, Zhang L, Zhang T, Lin W, Wen Z, Cao L*, Tan H. Effects of S-ketamine on Postoperative Recovery Quality and Inflammatory Response in Patients Undergoing Modified Radical Mastectomy. Pain Ther. 2023 Oct; 12(5):1165-1178.

5. Wu Z, Yu J, Zhang T, Tan H, Li H, Xie L, Lin W, Shen D, Cao L*. Effects of Etco2 on the Minimum Alveolar Concentration of Sevoflurane that Blunts the Adrenergic Response to Surgical Incision: A Prospective, Randomized, Double-Blinded Trial. Anesth Analg. 2022 Jul 1;135(1):62-70.

6. Wu Z, Yu J, Lin Q, Li H, Zhang T, Tan H, Lin W, Cao L*. Effects of an Intraoperative Intravenous Bolus Dose of Dexmedetomidine on Remifentanil-Induced Postinfusion Hyperalgesia in Patients Undergoing Thyroidectomy: A Double-Blind Randomized Controlled Trial. Anesth Analg. 2021 Feb 1;132(2):320-328.

7. Cao L, Chang Y, Lin W, Zhou J, Tan H, Yuan Y, Zeng W. Long-Term Survival after Resection of Hepatocelluar Carcinoma: A Potential Risk Associated with the Choice of Postoperative Analgesia. Anesth Analg. 2014 Jun;118(6):1309-16.

8. Cao L, Young N, Liu H, Silvestry S, Sun W, Zhao N, Diehl J, Sun J. Preoperative Aspirin Use and Outcomes in Cardiac Surgery Patients. Ann Surg 2012；255（2）：399-404.

9. Cao L, Silvestry S, Zhao N, Diehl J, Sun J. Effects of preoperative aspirin on cardiocerebral and renal complications in nonemergent cardiac surgery patients: a sub-group and cohort study. PLoS One. 2012;7(2):e30094.

10. Cao LH, Li HT, Lin WQ, Tan HY, Xie L, Zhong ZJ, Zhou JH. Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma xenografts. Sci Rep. 2016 Jan 5; 6:18706.

11. Liu C, Zhang T, Cao L, Lin W. Comparison of esketamine versus dexmedetomidine for attenuation of cardiovascular stress response to double-lumen tracheal tube intubation: a randomized controlled trial. Front Cardiovasc Med. 2023 Dec 21; 10:1289841.

12. Li HT, Tan F, Zhang TH, Cao LH, Tan HY, Lin WQ, Zeng WA, Chi XJ. Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro. BMC Pulm Med. 2022 May 12; 22(1):192.

13. Liu X, Cao L, Zhang T, Guo R, Lin W. Effect of Remote Ischemic Preconditioning in Patients Undergoing Hepatectomy With Portal Triad Clamping: A Randomized Controlled Trial. Anesth Analg. 2019 Dec;129(6):1742-1748

14. Li F, Li Q, Liu Y, Han J, Zheng W, Huang Y, Zheng X, Cao L*, Zhou JH*. Distinguishing intrahepatic cholangiocarcinoma from hepatocellular carcinoma in patients with and without risks: the evaluation of the LR-M criteria of contrast-enhanced ultrasound liverimaging reporting and data system version 2017. Eur Radiol. 2020; 30:461–470.

15. Han J, Li F, Peng C, Huang Y, Lin Q, Liu Y, Cao L*, Zhou J*. Reducing Unnecessary Biopsy of Breast Lesions: Preliminary Results with Combination of Strainand Shear-Wave Elastography. Ultrasound Med Biol. 2019; 45(9):2317-2327.

16. Huang Y, Li F, Han J, Peng C, Li Q, Cao L*, Liu Y, Zhou J*. Shear Wave Elastography of Breast Lesions: Quantitative Analysis of Elastic Heterogeneity Improves Diagnostic Performance. Ultrasound Med Biol. 2019;45(8):1909-1917.

17. Wang Y, Liu Y, Zheng X, Huang Y, Han J, Li F, Mao R, Li Q, Cao L*, Zhou J*. Added Value of Different Types of Elastography in Evaluating Ultrasonography Detected Breast Lesions: A Compared Study With Mammography. Clin Breast Cancer. 2020; 20(3):e366-e372.

18. Lin CY, Cao LH, et al. Ultrasonic spectrum analysis for in vivo characterization of tumor microstructural changes in the evaluation of tumor response to chemotherapy using diagnostic ultrasound.. BMC Cancer 2013;13:302.（co-first authors）

19. Zhou JH, Cao LH, et al. Contrast-enhanced gray-scale ultrasound for quantitative evaluation of tumor response to chemotherapy: preliminary results with a mouse hepatoma model. AJR Am J Roentgenol 2011；196 (1)：W13-W17. (co-first authors)

20. Sun JZ, Cao LH, et al. ACE inhibitors in cardiac surgery: current studies and controversies. Hypertens Res 2011; 34(1):15-22.

21. Zhou JH, Cao LH, et al. Quantitative assessment of tumor blood flow in mice after treatment with different doses of an antiangiogenic agent with contrast-enhanced destruction-replenishment US. Radiology; 2011;259(2):406-13

22. Zhou JH, Zheng W, Cao LH, et al. Quantitative evaluation of viable tissue perfusion changes with contrast-enhanced greyscale ultrasound in a mouse hepatoma model following treatment with different doses of thalidomide. Br J Radiol 2011;84(1005):826-32

23. Zhou JH, Zheng W, Cao LH, et al. Contrast-enhanced ultrasonic parametric perfusion imaging in the evaluation of antiangiogenic tumor treatment. Eur J Radiol 2011 Feb 21.

24. Zhou JH, Zheng W, Cao LH, et al. Antiangiogenic tumor treatment noninvasive monitoring with contrast pulse sequence imaging for contrast-enhanced grayscale ultrasound. Acad Radiol 2010; 17(5):646-651.

25. Zhou JH, Li AH, Cao LH, et al. Haemodynamic parameters of the hepatic artery and vein can detect liver metastases: the assessment using contrast-enhanced ultrasound. Br J Radiol 2008; 81(2):113-119.

26. Wu SY, Ling Q, Cao LH, et al.Real-time two-dimensional ultrasound guidance for central venous cannulation.:a meta-analysis. Anesthesiology;2013,118(2)

27. Wang JW, Zheng W, Chen Y, Cao LH, Luo RZ, Li AH, Zhou JH. Quantitative assessment of tumor blood flow changes in a murine breast cancer model after adriamycin chemotherapy using contrast-enhanced destruction-replenishment sonography. J Ultrasound Med. 2013; 32(4):683-90.

28. Wang JW, Zheng W, Liu JB, Chen Y, Cao LH, Luo RZ, Li AH, Zhou JH. Assessment of early tumor response to cytotoxic chemotherapy with dynamic contrast-enhanced ultrasound in human breast cancer xenografts. PLoS One 2013; 8(3):e58274.

更新时间：2024.07.08