李疆

 

教育经历（按时间倒排序）：
1999/9-2002/7，中山大学，博士，导师：张清炯
1992/9-1995/7，中山医科大学，硕士，导师：曾瑞萍
1987/9-1992/7，重庆医科大学，临床医学系，学士

工作经历（科研与学术工作经历，按时间倒排序）：
2015/1-至今，中山大学，肿瘤防治中心，生物治疗中心，研究员
2006/01-2014//12，中山大学，肿瘤防治中心，生物治疗中心，副研究员
2008/11-2010/03,美国BylorCollegeofMedicine，CenterforCellandGeneTherapy（Rong-FuWang实验室），博士后
2004/09－2005/03,瑞典Karolinska大学微生物与肿瘤生物学中心MariaGMasucci教授课题组,访问学者
2002/07-2005/12，中山大附属肿瘤医院，生物治疗中心，助理研究员
1995/07－1999/09,广东省人民医院老年医学研究所，助理研究员。

主持或参加科研项目及人才计划项目情况（按时间倒排序）：

 

例如：
1、国家自然科学基金面上项目，81972874、Galectin-9介导的CD8+T细胞重分化信号通路及其影响鼻咽癌免疫治疗的研究。2020/01-2023/12，60万元，主持。
2、国家自然科学基金面上项目，81773256、肿瘤微环境非编码RNA下调STING信号通路诱导T细胞功能耗竭的分子机制及其在鼻咽癌免疫治
疗中的作用，2018/01-2021/12、58万、主持
3、国家自然科学基金面上项目，81572982、EBV-LMP1上调鼻咽癌Warburg效应在肿瘤相关免疫细胞分化与功能调节中的作用和机制。2016/01-2019/12、55万、主持
4、国家自然科学基金面上项目，81372442、髓源性抑制细胞（MDSC）参与鼻咽癌免疫耐受的作用和调控机制、2014//01-2017/12、75万元、在研、主持。
5、国家自然科学基金面上项目，81172164、癌细胞分泌exosome改变CTL细胞功能导致鼻咽癌免疫逃逸的机制研究、20012/01-2014/12、55万元、在研、主持。
6、国家自然科学基金面上项目，30872981、调节性T淋巴细胞(Treg)与鼻咽癌免疫逃逸机理和临床相关性的研究、2008/01-2011/12、30万元、结题、主持。

 

 

部分代表文章：
 

1. Xu JX, Zhang R, Huang DJ, Tang Y, Ping LQ, Huang BJ, Huang HQ, Busson P, Li J. Galectin-9 Facilitates Epstein-Barr Virus Latent Infection and Lymphomagenesis in Human B Cells. Microbiol Spectr. 2023 Feb 14;11(1):e0493222. doi: 10.1128/spectrum.04932-22. Epub 2023 Jan 9. (IF = 9) （通讯作者）
2. Li H, Cao D, Li S, Chen B, Zhang Y, Zhu Y, Luo C, Lin W, Huang W, Ruan G, Zhang R, Li J, Liu L. Synergistic Association of Hepatitis B Surface Antigen and Plasma Epstein-Barr Virus DNA Load on Distant Metastasis in Patients With Nasopharyngeal Carcinoma. JAMA Netw Open. 2023 Feb 1;6(2):e2253832. doi: 10.1001/jamanetworkopen.2022.53832.PMID: 36757699 (IF = 13.3) （共同通讯作者）
3. Huang H, Nie C, Liu XF, Song B, Yue JH, Xu J, He J, Li K, Feng YL, Wan T, Zheng M, Zhang Y, Ye WJ, Li JD, Li YF, Li JY, Cao XP, Liu ZM, Zhang XS, Liu Q, Zhang X, Liu JH, Li J. Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer. J Clin Invest. 2022 Jun 21:e157726. doi: 10.1172/JCI157726. (IF = 19.8）（通讯作者）
4. Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, Li C, Xu JX, Nie CP, Li K, Zhang X, Xia X, Li J. T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer. J Immunother Cancer. 2022 Sep;10(9):e005151. doi: 10.1136/jitc-2022-005151. (IF = 14.5) （通讯作者）
5. Ni HH, Zhang L, Huang H, Dai SQ, Li J. Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer. J Transl Med. 2020 Oct 15;18(1):393. doi: 10.1186/s12967-020-02553-z. (IF = 5.5）（通讯作者）
6. Liu YN, Yang JF, Huang DJ, Ni HH, Zhang CX, Zhang L, He J, Gu JM, Chen HX, Mai HQ, Chen QY, Zhang XS, Gao S, Li J. Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways. Front Immunol. 2020 Aug 21;11:1906. doi: 10.3389/fimmu.2020.01906. (IF = 7.6）（通讯作者）
7. Zhang CX, Huang DJ, Baloche V, Zhang L, Xu JX, Li BW, Zhao XR, He J, Mai HQ, Chen QY, Zhang XS, Busson P, Cui J, Li J. Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation. Oncogenesis. 2020 Jul 6;9(7):65. doi: 10.1038/s41389-020-00248-0. (IF = 15.8) （通讯作者）
8. Zhang CX, Ye SB, Ni JJ, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX, Li J, Cui J. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019 Nov;26(11):2314-2328. doi: 10.1038/s41418-019-0302-0. (IF = 15.8）（共通讯作者）
9. Cai TT, Ye SB, Liu YN, He J, Chen QY, Mai HQ, Zhang CX, Cui J, Zhang XS, Busson P, Zeng YX, Li J. LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma. PLoS Pathog. 2017 Jul 21;13(7):e1006503. doi: 10.1371/journal.ppat.1006503. (IF = 6.5）（通讯作者）
10. Zhang H, Ye YL, Li MX, Ye SB, Huang WR, Cai TT, He J, Peng JY, Duan TH, Cui J, Zhang XS, Zhou FJ, Wang RF*, Li J*. CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer. Oncogene. 2016 Oct 10. doi: 10.1038/onc.2016.367. (IF = 9.1) （通讯作者）
11. Ye SB, Zhang H, Cai TT, Liu YN, Ni JJ, He J, Peng JY, Chen QY, Mo HY, Jun-Cui, Zhang XS, Zeng YX, Li J*. Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma. J Pathol. 2016 Nov;240(3):329-340. (IF = 7.4) （通讯作者）
12. Zhang H, Li ZL, Ye SB, Ouyang LY, Chen YS, He J, Huang HQ, Zeng YX, Zhang XS, Li J*. Myeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator. Cancer Immunol Immunother. 2015 Dec;64(12):1587-99. 2015 Dec; 64(12):1587-99. (IF = 4.6) （通讯作者）
13. Li ZL, Ye SB, OuYang LY, Zhang H, Chen YS, He J, Chen QY, Qian CN, Zhang XS, Cui J, Zeng YX, Li J. COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells. Oncoimmunology. 2015 Jul 9;4(11):e1044712. eCollection 2015 Nov. (IF = 7.6) （通讯作者）
14. Li J^#, Chen QY^#, He J, Li ZL, Tang XF, Chen SP, Xie CM, Li YQ, Huang LX, Ye SB, Ke ML, Tang LQ, Liu H, Zhang L, Guo SS, Xia JC, Zhang XS, Zheng LM, Guo X, Qian CN, Mai HQ*, Zeng YX*.Phase I Trial of Adoptively Transferred Tumor-infiltrating Lymphocyte Immunotherapy Following ConcurrentChemoradiotherapy in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma. Oncoimmunology. 2015.Mar 6; 2(4):e976507. (IF = 7.6) (第一作者)
15. Ye SB, Li ZL, Luo DH, Huang BJ, Chen YS, Zhang XS, Cui J, ZengYX, Li J*.Tumor-derived exosomes promote tumor progression and T-cell dysfunction throughthe regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014 Jul 30;5(14):5439-52.(IF = 5.2)（通讯作者）
16. OuYang LY#, Wu XJ#, Ye SB, Zhang RX, Li ZL, Liao W, Pan ZZ, Zheng LM, Zhang XS, Wang Z, Li Q, Ma G*, Li J*. Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer. JTransl Med. 2015 Feb 1;13(1):47. (IF = 3.99)（通讯作者）
17. Zhang L#, Ye SB#, Li ZL, Ma G, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.Increased HIF-1alpha expression in tumor cells and lymphocytes of tumormicroenvironments predicts unfavorable survival in esophageal squamous cellcarcinoma patients. Int J ClinExpPathol. 2014 Jun 15;7(7):3887-97.(IF = 1.78)（通讯作者）
18. Zhang L#, Ye SB#, Ma G, Tang XF, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.The expressions of MIF and CXCR4 protein in tumor microenvironment are adverseprognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013 Mar 8;11:60.(IF = 3.99)（通讯作者）
19. Li J#*, Mo HY#, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM, Zheng LM, Qian CN*, Zeng YX. Tumor microenvironment MIF directs the accumulation of IL-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem. 2012 Oct 12;287(42):35484-95.（第一，通讯作者）(IF=4.67)
20. [He J, Tang XF, Chen QY, Mai HQ, Huang ZF, Li J*, Zeng YX. Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapy. Chin J Cancer. 2012 Jun;31(6):287-94.（通讯作者）
21. Li J*, Huang ZF, Xiong G, Mo HY, Qiu F, Mai HQ, Chen QY, He J, Chen SP, Zheng LM, Qian CN, Zeng YX. Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma. J Transl Med. 2011 Nov 4;9(1):189. （第一，通讯作者）(SCI, IF=5.6(2011))
22. Zhang YL#, Li J#（共同第一作者）, Mo HY, Qiu F, Zheng LM, Qian CN, Zeng YX*. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways.  Mol Cancer. 2010 Jan 10; 9: 4. (第一作者是申请人的硕士研究生) (IF=27.4)