黄金圣

一、基本情况

副主任医师

出诊时间：每周二下午（黄埔院区）

                 每周四下午（越秀院区）

专业特长：师从中山大学名医、全国名老中医、广东省名中医张蓓教授，是张蓓教授传承工作室主要成员。从事恶性肿瘤的中西医结合治疗10余年，擅长常见肿瘤，包括消化系统肿瘤（结直肠癌、胃癌、食管癌、胰腺癌、肝癌、胆管癌）、肺癌、乳腺癌、妇科肿瘤等的内科治疗（化疗、靶向、免疫等），以及包括鼻咽癌等头颈部肿瘤的放射治疗后遗症、改善化疗后骨髓抑制及体力状况的中医治疗。强调“以人为本，带瘤生存”理念，倡导中医治疗贯穿于肿瘤防治的全过程，以促进患者术后康复、减轻放疗及化疗的毒副反应（减毒增效）、防止复发转移等。发表科研论文40余篇，其中第一作者和通讯作者SCI论文近20篇。参编《现代中西医结合临床肿瘤学》和《中国基本药材（第2版）》等学术专著。主持广东省中医药管理局、广东省卫生厅课题多项，参与重大项目多项。

二、学术任职

国家双核心期刊《现代肿瘤医学》青年编委

广东省中西医结合学会肿瘤专业委员会委员  

广东省精准医学应用学会肿瘤综合治疗分会委员

广东省抗癌协会传统医学专业委员会委员  

广东省中西医结合学会肿瘤康复专业委员会委员

广东省保健协会肿瘤防治与康复专业委员会委员  

广东省中西医结合学会肿瘤免疫专业委员会委员

广东省保健协会免疫细胞与干细胞治疗分会委员

广东省抗癌协会肿瘤多学科诊疗专业委员会委员

三、近年第一作者或通讯作者SCI论文

[1] Huang J, Kan J, Fan T, Quan Q, Li X, Jiang Q, Zhang B, Guo G. Efficacy of the Nourishing Yin and Clearing Heat Therapy Based on Traditional Chinese Medicine in the Prevention and Treatment of Radiotherapy-Induced Oral Mucositis in Nasopharyngeal Carcinomas: A Systematic Review and Meta-Analysis of Thirty Randomized Controlled Trials. Evid Based Complement Alternat Med. 2022 Apr 19;2022:4436361.

[2] Huang J, Li X, Jiang Q, Qiu H, Rong Y, Cui B, Guo G. Analysis of Risk Factors for Distant Metastasis of Pancreatic Ductal Adenocarcinoma without Regional Lymph Node Metastasis and a Nomogram Prediction Model for Survival. Evid Based Complement Alternat Med. 2023 Feb 21;2023:2916974.

[3] Huang J, Fan T, Rong Y, Li X, Jiang Q, Kan J, Qiu H, Quan Q, Zhang B, Guo G. Efficacy of Aidi injection combined with chemotherapy, radiotherapy or chemoradiotherapy for unresectable esophageal cancer treatment: A meta-analysis and systematic review of 29 randomized controlled trials based on Asian populations (China). Eur J Clin Pharmacol. 2023 Apr 12. 

[4] Huang J, Li X, Hong J, Huang L, Jiang Q, Guo S, Rong Y, Guo G. Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: a two-sample Mendelian randomization analysis of European and East Asian populations. Cancer Medicine. 2023.

[5] Long Q, Huang C, Huang J, Meng Q, Cheng Y, Li Y, He L, Chen M, Zhang C, Wang X, Zhu W, Peng J, Shi D, Zheng F, Dong P, Deng W. Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma. J Adv Res. 2022 Sep;40:153-166.

[6] Tian T, Lu Y, Lin J, Chen M, Qiu H, Zhu W, Sun H, Huang J, Yang H, Deng W. CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis. Redox Biol. 2022 Dec;58:102544.

[7] Jiang Q, Huang J, Zhang B, Li X, Chen X, Cui B, Li S, Guo G. Efficacy and Safety of Anti-PD1/PDL1 in Advanced Biliary Tract Cancer: A Systematic Review and Meta-Analysis. Front Immunol. 2022 Mar 2;13:801909.

[8] Li X, Huang J, Jiang C, Chen P, Quan Q, Jiang Q, Li S, Guo G. Comparison the efficacy and safety of different neoadjuvant regimens for resectable and borderline resectable pancreatic cancer: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2023 Mar;79(3):323-340.

[9] Wang Y, Chen P, Huang J, Liu M, Peng D, Li Z, Chen T, Hong S, Zhou Y. Assessment of sarcopenia as a predictor of poor overall survival for advanced non-small-cell lung cancer patients receiving salvage anti-PD-1 immunotherapy. Ann Transl Med. 2021 Dec;9(24):1801.

[10] Li XJ, Gao MG, Chen XX, Rong YM, Huang LL, Huang JS. Genetically Predicted Causal Effects of Gut Microbiota and Gut Metabolites on Digestive Tract Cancer: A Two-Sample Mendelian Randomization Analysis. World J Oncol. 2023 Dec;14(6):558-569.

[11] Hao J, Huang J, Hua C, Zuo Y, Yu W, Wu X, Li L, Xue G, Wan X, Ru L, Guo Z, Han S, Deng W, Lin F, Guo W. A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance. PLoS Biol. 2023 Sep 14;21(9):e3002256.

[12] Dong Y, Cao X, Huang J, Hu Z, Chen C, Chen M, Long Q, Xu Z, Lv D, Rong Y, Luo S, Wang H, Deng W, Tang B. Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166887.

[13] Li X, Huang J, Wang F, Jiang Q, Huang L, Li S, Guo G. Efficacy and safety of SOXIRI versus mFOLFIRINOX in advanced pancreatic cancer. Ther Adv Med Oncol. 2023 Jul 8;15:17588359231186029.

[14] Li XJ, Gao MG, Chen XX, Rong YM, Huang LL, Huang JS. Deciphering the causal association and co-disease mechanisms between psoriasis and breast cancer. Front Immunol. 2024 Mar.

[15] Gao M, Huang J, Yang B, Liu Q, Luo M, Yang B, Li X, Liu X. Identification of efferocytosis-related subtypes in gliomas and elucidating their characteristics and clinical significance. Front Cell Dev Biol. 2023 Dec 13;11:1295891.

[16] Huang L, Li X, Hong J, Huang J. Comment on "Psoriasis may increase the risk of lung cancer: A two-sample Mendelian randomization study". J Eur Acad Dermatol Venereol. 2024 Feb 5.

[17] Jin Y, Chen DL, Wang F, Yang CP, Chen XX, You JQ, Huang JS, Shao Y, Zhu DQ, Ouyang YM, Luo HY, Wang ZQ, Wang FH, Li YH, Xu RH, Zhang DS. The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors. Mol Cancer. 2020 Oct 30;19(1):154.

四、科研项目

[1] 沙参麦冬汤防治鼻咽癌放射性口腔干燥症的疗效量化及机制研究，广东省中医药管理局，2020，主持。

[2] 艾迪注射液联合同步放化疗治疗气虚血瘀型局部晚期食管癌的疗效与青紫舌/舌苔微生态/miRNA 的相关性研究，广东省中医药管理局，2022，主持

[3]《中西医结合防治鼻咽癌高水平临床研究》（广州市科技计划资助额500万元以上项目），参与

[4]《仙连解毒优化方预防结肠癌术后复发的临床研究》（国家重点研发计划），参与

[5] 广东省卫生厅，C2017058，肿瘤相关巨噬细胞预测贝伐珠单抗疗效的机制探讨，2017-12至2019-6，参与

[6] 广东省中医药局，20171068，通络化瘀方增强高级别脑胶质瘤化疗敏感性的作用研究，2017-1至2019-01，参与

[7] 广东省中医药局，20141056，基于光谱技术对不同辩证分型大肠癌患者舌诊客观化研究，2014-10至2016-12，参与

五、参编专著

[1] 《现代中西医结合临床肿瘤学》. 广东科技出版社. 撰写共5章计3.1万字（2019年广东省重点出版物暨“百部好书”扶持项目）

[2] 《中国基本药材（第2版）》. 中国医药科技出版社. 撰写共4章计1.3万字

更新时间：2024.05.13