杨弘
专长
一、基本情况
2016年中国肺癌精彩学术大赛卓越奖。2017年获亚洲心胸外科大会颁发的Furuse Awards杰出研究贡献奖。团队研究成果证实，术前放化疗并手术可延长局部晚期食管癌的总生存，将食管癌患者的中位生存期延长将近50%，奠定了“术前新辅助放化疗联合手术”治疗模式在国内外的地位。全球首创建立了立体定向放射序贯新辅助免疫联合化疗的新模式，治疗中晚期肺癌，显著提升疗效，将病理完全缓解率提升至52%。2019 - 2020年通过香港优才计划前往香港威尔斯亲王医院胸外科交流并获得香港行医执照。获2022年“人民好医生·金山茶花计划”食管癌领域杰出贡献专家称号。
以第一/通讯作者在Lancet、Journal of Clinical Oncology、Lancet Respiratory Medicine、Annals of Oncology、JAMA Surgery、Nature Communication等高水平期刊发表文章40余篇。主持国家级重大人才项目、国家自然科学基金项目、广东省科技计划项目等，科研经费逾千万。Lancet Onocolgy、Lancet Respiratory Medicine、Nature Communication、Signal Transduction and Targeted Therapy审稿专家。
出诊时间：越秀院区：周二 周三上午
二、教育及工作经历
2020–至今 中山大学肿瘤防治中心 胸外科 主任医师
2019 - 2020年 香港威尔斯亲王医院 微创胸外科 Fellow（香港优才计划）
2014 –至今 中山大学肿瘤防治中心 胸外科 副主任医师
2009 - 2014年 中山大学肿瘤防治中心 胸外科 主治医师
2006 - 2009年 中山大学肿瘤防治中心 外科 专科培训医师
三、学术兼职
华南肿瘤学重点实验室独立PI
国际肺癌研究协会会员
国家健康科普专家库专家
国家癌症中心食管癌质控专家委员会华南区协作组副组长
中国抗癌协会食管肿瘤整合康复专业委员会副主任委员
中国临床肿瘤学会(CSCO)青年专家委员会常务委员
中国抗癌协会食管癌专业委员会委员
广东省抗癌协会食管癌专业委员会副主任委员
广东省胸部肿瘤防治研究会靶向治疗专业委员会主任委员
广东省药学会第一届胸外科专家委员会副主任委员
四、代表性论著
1. Zhou S#, Wang Y#, Zhang R#, Zeng W, Liu S, Liu S, Liu M, Yang H*,Xi M*.Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy JAMA Netw Open. 2023-01-03;6(1):e2250965.
2. Zihang Mai# , Jiaxin Xie#, Changsen Leng#, Xiuying Xie, Jing Wen, Hong Yang*, Qianwen Liu*, Jianhua Fu*.An optimized post-surgery follow-up strategy for patients with esophageal cancer: a cohort study.Int J Surg. 2023 November 2.
3. Chen, Baoqing#；Liu，Shiliang#；Zhu, Yujia#；Wang, Ruixi#；Cheng, Xingyuan；Chen，Biqi；Dragomir，Mihnea P；Zhang，Yaru；Hu，Yonghong； Liu，Mengzhong；Li，Qiaoqiao*；Yang, Hong*；Xi，Mian*.Predictive role of ctDNA in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab.Nat Commun. 2024-03-01;15(1):1919.
4.Rui Chen#, Qianwen Liu#, Qiaoqiao Li#, Yujia Zhu#, Lei Zhao, Shiliang Liu, Baoqing Chen, Mengzhong Liu,Yonghong Hu, Ting Lin,Jibin Li, Jiyang Chen, Yingxin Lv, Jianhua Fu* , Mian Xi*, Hong Yang*.A phase II clinical trial of toripalimab combined with neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma (NEOCRTEC1901).EClinicalMedicine. 2023-08-01;62:102118.
5. Jianye Yuan#, Zelin Weng#, Zihui Tan#, Kongjia Luo#, Jian Zhong, Xiuying Xie a,c Chunhua Qu, Xiaodan Lin Hong Yang*, Jing Wen*, Jianhua Fu*.Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma. Cancer Letters. 2023-01-28;553:215959.
6. Zihang Mai#, Jianye Yuan#, Hong Yang#, Shuogui Fang#, Xiuying Xie, Xinye Wang, Jiaxin Xie, Jing Wen*, Jianhua Fu*. Inactivation of Hippo pathway characterizes a poor-prognosis subtype of esophageal cancer. JCI Insight. 2022;7(16): e155218 IF:9.496
7. Jing Wen*, Shuogui Fang#, Yi Hu#, Mian Xi#, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu*, Jianhua Fu*, and Hong Yang*. Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma. EBioMedicine .2022;86: 104371.
8. Hong Yang#, Hui Liu#, Yuping Chen#, Chengchu Zhu#, Wentao Fang#, Zhentao Yu#, Weimin Mao#, Jiaqing Xiang#, Yongtao Han#, Zhijian Chen#, Haihua Yang#, Jiaming Wang#, Qingsong Pang#, Xiao Zheng#, Huanjun Yang#, Tao Li#, Xu Zhang, Qun Li, Geng Wang, Baofu Chen, Teng Mao, Min Kong, Xufeng Guo, Ting Lin, Mengzhong Liu*, M Jianhua Fu*.Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma. JAMA Surgery.2168-6254. 2021,156(08): 721-729.Sun Yat-sen University Cancer Center.中科院一区.IF: 16.9
9. Xufeng Guo #, Zhexin Wang#; Hong Yang#, Teng Mao#, Yuping Chen, Chengchu Zhu, Zhentao Yu, Yongtao Han, Weimin Mao, Jiaqing Xiang, Zhijian Chen, Hui Liu, Haihua Yang,Jiaming Wang, Qingsong Pang, Xiao Zheng , Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Ting Lin, Mengzhong Liu, Jianhua Fu*, Wentao Fang*. Impact of Lymph Node Dissection on Survival after Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma. Annals of Surgery. 2023-02-01;277(2):259-266.
10. Shiliang Liu#, Jing Wen#, Hong Yang#, Qiaoqiao Li#, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Yongtao Han, Lei Zhao, Hui Liu, Yonghong Hu, Mengzhong Liu, Jianhua Fu*, Mian Xi*. Recurrence patterns after neoadjuvant chemoradiotherapy compared with surgery alone in oesophageal squamous cell carcinoma: results from the multicenter phase III trial NEOCRTEC5010.European Journal of Cancer. 2020-10-01;138:113-121.
11. Yan Huang, Yihuai Hu, , Yaobin Lin， Jianhua Fu, , Jiadi Wu, Caiyan Fang, Min Liu, and Yang Hong#.Evaluation of Fibrin Sealant in Prevention of Cervical Anastomotic Leakage After McKeown Esophagectomy: A Single Center, Retrospective Study. ANN SURG ONCOL. 2021-10-01;28(11):6390-6397. IF：4.339
12. Sha Zhou#， Hong Yang#, Jun Zhang#， Juncheng Wang, Zhaohui Liang, Songran Liu, Yong Li, Yanpeng Pan, MD, Lei Zhao, MD,* and Mian Xi, MD*.Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8D Tumor-Infifiltrating Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Signifificance in Esophageal Squamous Cell Carcinoma. International Journal of Radiation Oncology Biol Phys.2020 Jan; 108(1)286-294. IF: 8.013
13.Hong Yang#， Hui Liu#，Yuping Chen#，Chengchu Zhu#，Wentao Fang#， Zhentao Yu#，Weimin Mao#，Jiaqing Xiang#，Yongtao Han#，Zhijian Chen#， Haihua Yang#， Jiaming Wang#，Qingsong Pang#，Xiao Zheng#，Huanjun Yang#， Tao Li#,Florian Lordick，Xavier Benoit D’Journo， Robert J. Cerfolio，Robert J.Korst, Nuria M. Novoa， Scott J. Swanson，Alessandro Brunelli, Mahmoud Ismail，Hiran C. Fernando, Xu Zhang, Qun Li，Geng Wang, Baofu Chen, TengMao， Min Kong，Xufeng Guo，Ting Lin，Mengzhong Liu, Jianhua Fu,Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial. J Clin Oncol. 2018 Sep;36 (27): 2796-2803. IF:50.717
14. Li L#, Li JC#, Yang H#, Zhang X, Liu LL, Li Y, Zeng TT, Zhu YH, Li XD, Li Y, Xie D, Fu L, Guan XY*Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis.Proc Natl Acad Sci USA.2018Sep;115(38):E8948-E8957. IF:11.205
15. Yang YF#, Zhang MF#, Tian QH#, Fu J, Yang X, Zhang CZ*, Yang H*.SPAG5 interacts with CEP55 and exerts oncogenic activities via PI3K/AKT pathway in hepatocellular carcinoma.Mol Cancer.2018 Aug;17(1):117. IF:27.401
16. Wen Jing#, Hu Yi#, Liu Qianwen#,Ling Yihong, Zhang Shuishen, Luo Kongjia, Xie Xiuying, Fu Jianhua*, Yang Hong*.miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation.EBioMedicine.2018Nov;37:110-124. IF:8.143
17. Lei Li#, Hong Yang#, Yan Li1, Xiao-Dong Li, TingTing Zeng, Su-Xia Lin, Ying-Hui Zhu* and XinYuan Guan*.Hypoxia restrains the expression ofcomplement component 9 in tumorassociated macrop-hages promotingnon small cell lungcancer progression.Cell Death Discovery.2018;4(63):2-12. IF:5.241
18. Jianwei Wang #, Min Liu #, Jingxian Shen# , Haichao Ouyang #, Xiuying Xie#, Ting Lin#, Anhua Li*and Hong Yang *.Diagnostic value of intraoperative ultrasonography in assessing thoracic recurrent laryngeal nerve lymph nodes in patients with esophageal cancer.BMC Cancer. 2018 July;18(1):737. IF:4.43
19. Jing-Sheng Zeng, Zhen-Dong Zhang, Li Pei, Zhi-Zhu Bai, Yong Yang, Hong Yang*,Qiu-Hong Tian*.CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling.Int J Biochem Cell Biol. 2018 Feb;95:1-8. IF:5.058
20. Bo Qiu#, JiaXiang Li# , Bin Wang# , ZhiQiang Wang, Ying Liang , Peiqiang Cai, ZhaoLin Chen , MengZhong Liu, JianHua Fu， Hong Yang*, Hui Liu*.Adjuvant Therapy for a Microscopically Incomplete Resection Margin after an Esophagectomy for Esophageal Squamous Cell Carcinoma.J Cancer.2017 Jan;8(2):249-257. IF:4.207
21. Liu M#, Hu Y#, Zhang MF#, Luo KJ, Xie XY, Wen J, Fu JH, Yang H*.MMP1 promotes tumor growth and metastasis in esophageal squamous cell carcinoma.Cancer Lett.2016 July;377(1):97-104. IF:8.679
22. Bo Qiu#, De Ling Wang#, Hong Yang#, Wei Hao Xie, Ying Liang, Pei qiang Cai ZhaoLin 19.Chen, Meng Zhong Liu, JianHua Fu, Chuan Miao Xie*, Hui Liu*Combined modalities of magnetic resonance imaging, endoscopy and computed tomography in the evaluation of tumor responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma. Radiotherapy and Oncology. 2016 Nov;121(2):239-245. IF: 6.28
23. Song Ran Liu#, Bo Qiu#, Hong Yang#, Ying Liang, Fang Wang, Shi Liang Liu, Zhao Lin Chen, Li Zhang, Meng Zhong Liu, Si Yu Wang, Lan Feng Lin*, and Hui Liu*.Epidermal Growth Factor Receptor Mutation Status and Treatment Outcome for R0-Resected Patients with Stage 3 Non-small Cell Lung Cancer.Ann Surg Oncol. 2016 Jan;23(6):2115-22. IF:5.344
24. Liu SL#, Yang H#, Zhang P#, Zhang L, Zhao L, Luo LL, Fu JH, Liu MZ, Xi M*.Neoadjuvant chemoradiotherapy with cisplatin plus vinorelbine versus cisplatin plus fluorouracil for esophageal squamous cell carcinoma: A matched case-control study. Radiotherapy and Oncology. 2016;121(2):239~245. IF:6.28
25. Huang QY#, Luo KJ#, Yang H#, Wen J, Zhang SS, Li JH, Bella AE, Liu QW, Yang F, Zheng YZ, Hu RG,Chen JY, Fu JH*. Impact of alcohol consumption on survival in patients with esophageal carcinoma:a large cohort with long-term follow-up.Cancer Sci. 2014;105(12):1638-1646. IF:6.419
26. Wen J#, Yang H#, Liu MZ#, Luo KJ, Liu H, Hu Y, Zhang X, Lai RC, Lin T, Wang HY, Fu JH*.Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy.Ann Oncol.2014;25（9）:1769~1774. IF:32.924
27. Zhang SS#, Yang H#, Luo KJ#, Huang QY, Chen JY, Yang F, Cai XL, Xie X, Liu QW, Bella AE, Hu RG, Wen J, Hu Y, Fu JH(*).The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.Br J Cancer.2013;109(11)：2894~2903. IF:7.64
更新时间：2024.12.13
