刘盼盼

一、基本情况

姓名：刘盼盼

职称：主任医师、博士生导师

擅长：淋巴瘤、头颈部肿瘤的内科治疗及相关研究

出诊时间及诊室：周一下午（304诊室），周五上午（309诊室）

二、个人简介

中山大学肿瘤学博士，美国MD Anderson癌症中心交流访问学者。从事淋巴瘤及头颈肿瘤的内科治疗（包含免疫化疗、靶向治疗及CAR-T细胞疗法），具有丰富的临床经验；科学研究方向聚焦于基于临床重大问题的基础转化研究，从代谢角度深入研究肿瘤发生发展和耐药机制，探索肿瘤代谢特征与临床表型的内在联系和关键环节及靶向干预。以通讯作者或第一作者在Cell Death & Differentiation、Molecular Cancer、 Redox Biology、Haematologica、Cancer Communications、STTT、Oncogene等杂志发表多篇高水平论文。主持国家自然科学基金青年及面上项目、广东省自然科学基金、广州市科技计划重点研发项目、中山大学青年教师培育项目等多项研究课题。

三、代表性论著

1. HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2. Liu PP, Luo Y, Wu HY, Han Y, Wang SJ, Liu R, Wen SJ, Huang P. Cell Death & Differentiation. 2024.

2. The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism. Yang MQ, Liu JX, Li JN, Wen SJ, Hu YM, Lu WH, Liu JY*, Huang P*, Liu PP*. Redox Biology. 2024.

3. Global miRNA profiling reveals key molecules that contribute to different chronic lymphocytic leukemia incidences in Asian and Western populations. Liu PP, Wang KF, Li JN, Ogasawara MA, Xia ZJ, Wierda WG, Keating MJ, Li YQ, Huang P. Haematologica. 2024.

4. Malignant transformation by oncogenic K-ras requires IDH2-mediated reductive carboxylation to promote glutamine utilization. Liu R^#, Liu PP^#, Bi HC, Ling JH, Zhang H, Zhang MQ, Hu YM, Chiao PJ, Huang P, Liu JY. Cancer Communications (Lond). 2023.

5. Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma. Cai J^#, Liu PP^#, Huang HQ^#, Li YJ, Ma SY, Zhou H, Tian XP, Zhang YC, Gao Y, Xia Y, Zhang XY, Yang H, Li LR, Cai QQ. Signal Transduction and Targeted Therapy. 2020.

6. Overexpression of GLT1D1 induces immunosuppression through glycosylation of PD-L1 and predicts poor prognosis in B-cell lymphoma. Liu XX, Zhang YY, Han Y, Lu WH, Yang J, Tian JY, Sun P, Yu TT, Hu YM, Zhang H*, Huang P*, Liu PP*. Molecular Oncology. 2020.

7. Modulation of energy metabolism to overcome drug resistance in chronic myeloid leukemia cells through induction of autophagy. Li YQ*, Zeng PT, Xiao J, Huang P, Liu PP*. Cell Death Discovery. 2022.

8. Regulation of stem-like cancer cells by glutamine through beta-catenin pathway mediated by redox signaling. Liao JW^#, Liu PP^#, Hou GX, Shao JJ, Yang J, Liu KY, Lu WH, Wen SJ, Hu YM, Huang P. Molecular Cancer. 2017.

9. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline. Liu PP, Liu JY, Jiang WQ, Carew JS, Ogasawara MA, Pelicano H, Croce CM, Estrov Z, Xu RH, Keating MJ, Huang P. Oncogene. 2016.

10. Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway. Liu PP, Liao J, Tang ZJ, Wu WJ, Yang J, Zeng ZL, Hu Ym, Wang P, Ju HQ, Xu RH, Huang P. Cell Death & Differentiation. 2014.

更新时间：2024.10.18