博士后合作导师
李婧
职称：副研究员，博士生导师
实验室地址：黄埔院区腾飞园F座9楼
个人主页：https://iyeast.wordpress.com/
教育和工作经历
2019.11-现在 副研究员，中山大学肿瘤防治中心，实验研究部
2014.08-2019.09 博士后，法国国家科学研究中心 (CNRS)，尼斯癌症与衰老研究所 (IRCAN)，导师：Gianni Liti
2009.09-2014.06 生物学博士，南京大学，生命科学学院，导师：田大成
2005.09-2009.06 生物科学学士，南京大学，生命科学学院
荣誉和获奖情况
2024 中山大学肿瘤防治中心“优青提升计划”
2022 广东省珠江人才计划“青年拔尖人才”
2019 中山大学“百人计划”
2014 法国ARC癌症基金会博士后奖学金
2014 南京大学“五四青年奖章”，南京大学优秀毕业生
2013 国家奖学金
研究领域：遗传、演化和基因组学
研究方向：
- 肺癌抗肿瘤治疗的耐药演化和机制
- 抗肿瘤治疗的突变印记和诱变机制
- 非整倍体的基因组不稳定性
代表性论文
co-1st author: # corresponding author: *
- Jiani Zheng#; Shen Zhao#; Jianhua Zhan#; Weitao Zhuang#; Maojian Chen#; Wei Jiang#; Yihua Huang; Junyi He; Liyang Hu; Lanlan Pang; Feng Hao; Jinhui Xue; Mengting Shi; Anlin Li; Jingxun Wu; Shaodong Hong; Yuanyuan Zhao; Feng Ye; Yan Huang; Hongyun Zhao; Yunpeng Yang; Wenfeng Fang*; Li Zhang*; Jing Li* (2026) The oncogenic EGFR-SHC1 fusion confers insensitivity to EGFR-TKI via dual activation of N-EGFR kinase domain and C-SHC1 phosphorylation sites in lung cancer. Cancer Discovery. Online First March 24, 2026. doi.org/10.1158/2159-8290.CD-25-1936
- Maojian Chen#, Wei Jiang#, Jianhua Zhan#, Shaoping Zhang#, Jiani Zheng#, Yihua Huang, Junyi He, Yunpeng Yang, Shen Zhao, Yaxiong Zhang, Jiaqing Liu, Lanlan Pang, Li Zhang*, Wenfeng Fang*, Jing Li*. (2025) Activating NEDD4L suppresses EGFR-driven lung adenocarcinoma growth via facilitating EGFR proteasomal degradation. Journal of Experimental & Clinical Cancer Research volume 44, Article number: 294
- Yihua Huang#, Jie Huang#, Jianhua Zhan#, Maojian Chen#, Jiani Zheng, Junyi He, Wenfeng Fang*, Li Zhang*, Jing Li*. (2025) CCN1 is a therapeutic target upregulated in EML4-ALK mutant lung adenocarcinoma reversibly resistant to alectinib. Cell Death & Disease. 2025 Apr 15;16(1):303.
- Zepu Miao#, Yifan Ren#, Andrea Tarabini#, Ludong Yang, Huihui Li, Chang Ye, Gianni Liti, Gilles Fischer, Jing Li*, Jia-Xing Yue*. (2024) ScRAPdb: an integrated pan-omics database for the Saccharomyces cerevisiae reference assembly panel. Nucleic Acids Research. 2024 Oct 29:gkae955.
- Ludong Yang#, Xinxin Zhang#, Fan Wang#, Li Zhang*, Jing Li*, Jia-Xing Yue*. (2024) NanoTrans: an integrated computational framework for comprehensive transcriptome analysis with Nanopore direct RNA sequencing. Journal of Genetics and Genomics. 2024 Nov;51(11):1300-1309.
- Xinyu Tu#, Fan Wang#, Gianni Liti, Michael Breitenbach, Jia-Xing Yue*, Jing Li* (2023) Spontaneous Mutation Rates and Spectra of Respiratory-Deficient Yeast. Biomolecules. 2023, 13, 501.
- Jing Li, Simon Stenberg, Jia-Xing Yue, Ekaterina Mikhalev, Dawn Thompson, Jonas Warringer, Gianni Liti* (2023) Genome instability footprint under rapamycin and hydroxyurea treatments. PLoS Genetics 19(11): e1011012.
- Samuel O’Donnell#, Jia-Xing Yue#, Omar Abou Saada, Nicolas Agier, Claudia Caradec, Thomas Cokelaer, Matteo De Chiara, Stéphane Delmas, Fabien Dutreux, Téo Fournier, Anne Friedrich, Etienne Kornobis, Jing Li, Zepu Miao, Lorenzo Tattini, Joseph Schacherer*, Gianni Liti* & Gilles Fischer* (2023) Telomere-to-telomere assemblies of 142 strains characterize the genome structural landscape in Saccharomyces cerevisiae. Nature Genetics. 55, 1390–1399
- Jing Li, Bertrand Llorente, Gianni Liti*, Jia-Xing Yue* (2022) RecombineX: A generalized computational framework for automatic high-throughput gamete genotyping and tetrad-based recombination analysis. PLoS Genetics 18(5): e1010047.
- Xinru Chen#, Xiangchan Hong#, Gang Chen#, Jinhui Xue, Jie Huang, Fan Wang, Wael Ab dullah Sultan Ali, Jing Li*, Li Zhang* (2022) The Pan-Immune-Inflammation Value predicts the survival of patients with anaplastic lymphoma kinase-positive non-small cell lung cancer treated with first-line ALK inhibitor. Translational Oncology. 2022 Mar:17:101338
主持的科研项目
- 中山大学肿瘤防治中心“优青提升计划”，2024-至今
- 广东省自然科学基金，面上项目，2022-2024
- 国家自然科学基金，青年基金项目，2021-2023
- 广州市科技计划项目，基础研究计划，2021-2023
- 中山大学“百人计划”，2019-2022
更新日期：2026年4月2日
