博士后合作导师

张继

职称：博士生导师

张继，医学博士、博士生导师，毕业于四川大学华西临床医学系。担任广东省医学教育协会神外专业委员会副主委、科技部中信所科技专家、广东省科技咨询专家、“百县千镇万村高质量发展工程”卫生健康领域省级专家等。临床专长：脊髓脊柱肿瘤微创手术、胶质瘤及脑转移瘤的综合治疗、颅底肿瘤手术治疗、垂体瘤经鼻内镜手术。科研方向：胶质瘤免疫治疗抵抗的机制：探索巨噬细胞在胶质瘤免疫治疗中抵抗的机制。至今主持国家自然科学基金面上项目、广东省自然科学基金等基金6项。发表SCI论文20篇，获批专利6项，参编书籍2部。

近五年发表的部分论文

  1. Zhang, J., ...., Sun, X.Q.*, Single-cell transcriptome-based multilayer network biomarker for predicting prognosis and therapeutic response of gliomas. Briefings in Bioinformatics.2020;21(3):1080-97.
  2. Mei Y, Wang X, Zhang J,..., Jia G. Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response. Nature Cancer. 2023; 4(9):1273-91.
  3. Ni X,..., Zhang J, Chen Z. Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma. Science Advances. 2022;8(27):eabl5165.
  4. Wang, J., Zhang, J..., Ling. L.S.* Strand displacement amplification-coupled dynamic light scattering method to detect urinary telomerase for non-invasive detection of bladder cancer. Biosens. Bioelectron. 2019, 15(131):143-8.
  5. Zou, L.*, Li,X.H., Zhang, J.*, Ling, L.S.* A Highly Sensitive Catalytic Hairpin Assembly-Based Dynamic Light-Scattering Biosensors for Telomerase Detection in Bladder Cancer Diagnosis. Anal. Chem., 2020, 92(18),12656-662.
  6. Shen, R.D. #, Zhang, J. #, Huang, W.X., Wu, S.Y., Li, G.K., Zou, S.Y.*, Ling, L.S.* Dynamic light scattering and fluorescence dual-signal sensing of cancer antigen-125 via recognition of the polymerase chain reaction product with gold nanoparticle probe. Analytica Chimica Acta, 2021;1145:87-94.
  7. Li, T.T.#, Zou, L.#, Zhang, J.#, Li, G.K., Ling, L.S.* Non-invasive diagnosis of bladder cancer by detecting telomerase activity in human urine using hybridization chain reaction and dynamic light scattering. Anal Chim Acta. 2019,1065: 90-97.
  8. Zhang, J.#, Sai, K.#, Wang, X.L.#, Ye, S.Q, Liang, L.J, Zhou, Y., Chen, Z.J, Hu, W.M.*, Liu, J. M.*. Tim-3 Expression and MGMT Methylation Status Association With Survival in Glioblastoma. Front Pharmacol. 2020,11,584652.
  9. Zhu Z.#, Zhang X.#, Yu Z.#, Zhou Y, Zhu S, Zhang YH, Lin, X.P.*, Mou, Y.*, Zhang, J.* Correlation of Tim-3 expression with chemokine levels for predicting the prognosis of patients with glioblastoma. J Neuroimmunol. 2021; 355:577575.

近年基金选录

  1. 国家自然科学基金面上项目，82473347，CCL3L3-CCR1介导巨噬细胞亚群互作促进胶质母细胞抵抗新辅助“双抗”免疫治疗的机制研究，2025/01-2028/12，在研，主持
  2. 广东省基础与应用基础研究基金面上项目, 2022A1515012539, GBM中PTEN基因缺失及Tim-3/Gal-9信号通路对巨噬细胞M2极化的影响及机制研究, 2022/01-2024/12,  在研, 主持
  3. 高校基本科研业务费, 中山大学青年教师培育项目, 19ykpy190, 干预Tim-3逆转巨噬细胞M2极化及胶质瘤耐药性的机制研究, 2019/01-2021/12，结题, 主持