廖丹
专长
主要简介：
2014年毕业于中山大学肿瘤防治中心康铁邦教授课题组，获得肿瘤学博士学位，同年进入中山大学进行博士后，特聘副究员研究。2020年转聘中山大学肿瘤防治中心副研究员工作。先后获得广东省杰青（2020年），国家基金委肿瘤学优青（2023年）人才项目。现任中山大学华南恶性肿瘤防治全国重点实验室PI，副研究员职务。近年来，主要致力于研究肿瘤转移及免疫微环境的表观调控；蛋白翻译后修饰的分子机制研究，以通讯作者或第一作者在Nat Cell Biol，Sci Adv, Adv. Sci，Clin Cancer Res, Signal Transduct Target Ther, Cancer Lett, Theranostics等国际主流期刊发表SCI论文。作为主要发明人共获得授权发明专利2项。
联系方式：广州市东风东路651号，中山大学肿瘤防治中心2号楼808室，510060；
在研主持科研项目：
1. 国家自然优秀青年科学基金项目，H1809，2024.01-2026.12，200元，在研, 主持
2. 国家自然科学基金面上项目, 32370819， 2024.01-2027.12, 50万元, 在研, 主持
3. 国家自然科学基金面上项目, 32070765， 2021.01-2024.12, 58万元, 在研, 主持
4. 广东省杰出青年基金，2021.01-2024.12, 100万，在研，主持
近五年代表性研究成果：
1. Liao, Dan; Zhong, Li; Yin, Junqiang; Zeng, Cuiling; Wang, Xin; Huang, Xingchuan; Chen,Jinna; Zhang, Hong; Zhang, Ruhua; Guan, Xin-Yuan; Shuai, Xintao; Sui, Jianhua; Gao, Song; Deng,Wuguo; Zeng, Yi-Xin; Shen, Jing-Nan; Chen, Jian; Kang, Tiebang ; Chromosomal translocationderived aberrant Rab22a drives metastasis of osteosarcoma, Nature Cell Biology, 2020, 22(7): 868-881
2. Cuiling Zeng; Li Zhong; Wenqiang Liu; Yu Zhang; Xinhao Yu; Xin Wang; Ruhua Zhang; Tiebang Kang; Dan Liao ; Targeting the Lysosomal Degradation of Rab22a‐NeoF1 Fusion Protein for Osteosarcoma Lung Metastasis, Advanced Science, 2023.Feb, 10(5): e2205483
3. Li Zhong; Jingxuan Wang; Wanqi Chen; Dongming Lv; Ruhua Zhang; Xin Wang; Cuiling Zeng; Xiaobo He; Lisi Zheng; Ying Gao; Shang Wang; Miao Li; Yuanzhong Wu; Junqiang Yin, Tiebang Kang, Dan Liao; Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma. Sci Adv. 2023 Nov 24;9(47):eadi0889.
4. Weijie Gao; Jing Zhou; Jintao Huang; Zhiguang Zhang; Wanqi Chen; Ruhua Zhang; Tiebang Kang; Dan Liao; Li Zhong; Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. Cancer Lett. 2024 Apr 1:586:216708.
5. Zhong, Li; Liao, Dan; Li, Jingjing; Liu, Wenqiang; Wang, Jingxuan; Zeng, Cuiling; Wang,Xin; Cao, Zhiliang; Zhang, Ruhua; Li, Miao; Jiang, Kuntai; Zeng, Yi-Xin; Sui, Jianhua; Kang,Tiebang ; Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes, Signal Transduction and Targeted Therapy, 2021, 6(1): 0-59
6. Zhong Li; Liao Dan; Zhang Meifang; Zeng Cuiling; Li Xinchun; Zhang Ruhua; Ma Haiqing;
Kang Tiebang ; YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma, Cancer Letters, 2019, 442: 252-261
7. Liang, Xiaoting; Wang, Xin; He, Yaohui; Wu, Yuanzhong; Zhong, Li; Liu, Wen; Liao, Dan; Kang, Tiebang ; Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma,Theranostics, 2020, 10(17): 7747-7757
8. Liao Dan; Zhong Li; Duan Tingmei; Zhang Ru Hua; Wang Xin; Wang Gang; Hu Kaishun; Lv
Xiaobin; Kang Tiebang ; Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-kappa B Pathway, Clinical Cancer Research, 2015, 21(23): 5349-5359
授权专利：
(1) 康铁邦; 廖丹; 钟理; 沈靖南; 隋建华 ; 一种用于治疗骨肉瘤的靶向多肽及其应用, 2018-12-6, 中国, CN201811490126.6 (专利)
(2) 康铁邦; 廖丹; 钟理; 沈靖南; 隋建华 ; 一种用于诊断和/或治疗骨肉瘤的RAB22A-NoeFs融合基因系及其应用, 2018-4-28, 中国, CN201810404047.2 (专利)
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主要简介：
2014年毕业于中山大学肿瘤防治中心康铁邦教授课题组，获得肿瘤学博士学位，同年进入中山大学进行博士后，特聘副究员研究。2020年转聘中山大学肿瘤防治中心副研究员工作。先后获得广东省杰青（2020年），国家基金委肿瘤学优青（2023年）人才项目。现任中山大学华南恶性肿瘤防治全国重点实验室PI，副研究员职务。近年来，主要致力于研究肿瘤转移及免疫微环境的表观调控；蛋白翻译后修饰的分子机制研究，以通讯作者或第一作者在Nat Cell Biol，Sci Adv, Adv. Sci，Clin Cancer Res, Signal Transduct Target Ther, Cancer Lett, Theranostics等国际主流期刊发表SCI论文。作为主要发明人共获得授权发明专利2项。
联系方式：广州市东风东路651号，中山大学肿瘤防治中心2号楼808室，510060；
在研主持科研项目：
1. 国家自然优秀青年科学基金项目，H1809，2024.01-2026.12，200元，在研, 主持
2. 国家自然科学基金面上项目, 32370819， 2024.01-2027.12, 50万元, 在研, 主持
3. 国家自然科学基金面上项目, 32070765， 2021.01-2024.12, 58万元, 在研, 主持
4. 广东省杰出青年基金，2021.01-2024.12, 100万，在研，主持
近五年代表性研究成果：
1. Liao, Dan; Zhong, Li; Yin, Junqiang; Zeng, Cuiling; Wang, Xin; Huang, Xingchuan; Chen,Jinna; Zhang, Hong; Zhang, Ruhua; Guan, Xin-Yuan; Shuai, Xintao; Sui, Jianhua; Gao, Song; Deng,Wuguo; Zeng, Yi-Xin; Shen, Jing-Nan; Chen, Jian; Kang, Tiebang ; Chromosomal translocationderived aberrant Rab22a drives metastasis of osteosarcoma, Nature Cell Biology, 2020, 22(7): 868-881
2. Cuiling Zeng; Li Zhong; Wenqiang Liu; Yu Zhang; Xinhao Yu; Xin Wang; Ruhua Zhang; Tiebang Kang; Dan Liao ; Targeting the Lysosomal Degradation of Rab22a‐NeoF1 Fusion Protein for Osteosarcoma Lung Metastasis, Advanced Science, 2023.Feb, 10(5): e2205483
3. Li Zhong; Jingxuan Wang; Wanqi Chen; Dongming Lv; Ruhua Zhang; Xin Wang; Cuiling Zeng; Xiaobo He; Lisi Zheng; Ying Gao; Shang Wang; Miao Li; Yuanzhong Wu; Junqiang Yin, Tiebang Kang, Dan Liao; Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma. Sci Adv. 2023 Nov 24;9(47):eadi0889.
4. Weijie Gao; Jing Zhou; Jintao Huang; Zhiguang Zhang; Wanqi Chen; Ruhua Zhang; Tiebang Kang; Dan Liao; Li Zhong; Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. Cancer Lett. 2024 Apr 1:586:216708.
5. Zhong, Li; Liao, Dan; Li, Jingjing; Liu, Wenqiang; Wang, Jingxuan; Zeng, Cuiling; Wang,Xin; Cao, Zhiliang; Zhang, Ruhua; Li, Miao; Jiang, Kuntai; Zeng, Yi-Xin; Sui, Jianhua; Kang,Tiebang ; Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes, Signal Transduction and Targeted Therapy, 2021, 6(1): 0-59
6. Zhong Li; Liao Dan; Zhang Meifang; Zeng Cuiling; Li Xinchun; Zhang Ruhua; Ma Haiqing;
Kang Tiebang ; YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma, Cancer Letters, 2019, 442: 252-261
7. Liang, Xiaoting; Wang, Xin; He, Yaohui; Wu, Yuanzhong; Zhong, Li; Liu, Wen; Liao, Dan; Kang, Tiebang ; Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma,Theranostics, 2020, 10(17): 7747-7757
8. Liao Dan; Zhong Li; Duan Tingmei; Zhang Ru Hua; Wang Xin; Wang Gang; Hu Kaishun; Lv
Xiaobin; Kang Tiebang ; Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-kappa B Pathway, Clinical Cancer Research, 2015, 21(23): 5349-5359
授权专利：
(1) 康铁邦; 廖丹; 钟理; 沈靖南; 隋建华 ; 一种用于治疗骨肉瘤的靶向多肽及其应用, 2018-12-6, 中国, CN201811490126.6 (专利)
(2) 康铁邦; 廖丹; 钟理; 沈靖南; 隋建华 ; 一种用于诊断和/或治疗骨肉瘤的RAB22A-NoeFs融合基因系及其应用, 2018-4-28, 中国, CN201810404047.2 (专利)
