廖雯婷
专长
结直肠癌转移分子机制
结直肠癌免疫逃逸和免疫治疗耐药机制
转移性结直肠癌治疗新靶点探索及新药开发
地址：广州中新知识城腾飞园F栋10楼，华南恶性肿瘤防治全国重点实验室（黄埔区）
实验室网站：https://immunotranslab.github.io/
个人简介：廖雯婷，中山大学“百人计划”引进人才；中山大学肿瘤防治中心、华南恶性肿瘤防治全国重点实验室PI。广东省精准医学应用学会分子病理分会常务委员、广东省抗癌协会肿瘤转移专业委员会委员、广东省临床医学学会肿瘤免疫治疗专业委员会委员、广东省人才交流协会智库专家。以通讯/第一作者在Science Immunology、Cancer cell、Nature communications、JCI 等顶尖杂志发表论文 20余篇，入选ESI高被引论文；主持数项国家自然科学基金和广东省自然科学基金；入选 2022、2023、2024 全球前 2%顶尖科学家“年度科学影响力排行榜”。
代表性论著：（#第一作者，*通讯作者）
（更多代表作：https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/）
1. Zhou Y#, Zhang Y#, Li M#, Ming T#, Zhang C, Huang C, Li J, Li F, Li H, Zhao E, Shu F, Liu L, Pan X, Gao Y, Tian L, Song L*, Huang H*, Liao W*. Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry. Sci Immunol. 2024 Oct 4;9(100):1.
2. Zhou Y#, Li H#, Zhang Y#, Zhao E, Huang C, Pan X, Shu F, Liu Z, Tang N*, Li F*, Liao W*. Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer. Cancer Lett, 2024 May 1:589:216836.
3. Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K, Jr., Hsu WH, Lee R, Khanduri I, Terranova C, Akdemir K, Chakravarti D, Shang X, Spring DJ, Wang YA, DePinho RA. Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature, 2023; 619, 632-639.
4. Zhu Y#, Huang C#, Zhang C#, Zhou Y#, Zhao E, Zhang Y, Pan X, Huang H*, Liao W*, Wang X*. LncRNA MIR200CHG inhibits epithelial-mesenchymal transition in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation. Nat Commun, 2023; 14: 8141.
5. Li M#, Huang C#, Wu Y#, Zhu L, Zhang Y, Zhou Y, Li H, Liu Z, Pan X, Wang X, Qiu J*, Li F*, Liao W*. Long non-coding RNA CCL14-AS suppresses invasiveness and lymph node metastasis of colorectal cancer cells by regulating MEP1A. Cancer Cell Int, 2023 Feb 15;23(1):27-42.
6. Shi D#, Wu X#, Jian Y#, Wang J#, Huang C, Mo S, Li Y, Li F, Zhang C, Zhang D, Zhang H, Huang H, Chen X, Wang YA, Lin C, Liu G*, Song L*, Liao W*. USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer. Nat Commun. 2022 Sep 26;13(1):5644.; 13, 5644.
7. Huang C#, Ou R#, Chen X#, Zhang Y, Li J, Liang Y, Zhu X, Liu L, Li M, Lin D, Qiu J, Liu G, Zhang L, Wu Y, Tang H, Liu Y, Liang L, Ding Y*, Liao W*. Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC. J Exp Clin Cancer Res. 2021 Sep 28;40(1):304.
8. Wang S#, Qiu J#, Liu L#, Su C, Qi L, Huang C, Chen X, Zhang Y, Ye Y, Ding Y, Liang L*, Liao W*. CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET. J Exp Clin Cancer Res. 2020 Aug 25;39(1):168.
9. Zhu X#, Wang F#, Wu X, Li Z, Wang Z, Ren X, Zhou Y, Song F, Liang Y, Zeng Z, Liao W, Ding Y, Liao W*, Liang L*. FBX8 promotes metastatic dormancy of colorectal cancer in liver. Cell Death Dis. 2020 Aug 14;11(8):622.
10. Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA*, DePinho RA*. KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer. Cancer Cell, 2019 Apr 15;35(4):559-572.
