尧凯
尧凯，男，医学博士，共产党员，中山大学附属肿瘤医院泌尿外科科主任，主任医师，博士生导师。2007年博士毕业后一直在中山大学附属肿瘤医院泌尿外科工作。对泌尿男生殖系肿瘤的诊治具有丰富的临床经验，已主刀完成泌尿肿瘤手术8000余台。主持国家自然基金项目和省部级项目多项，参编专著8本。 在国内外主流杂志发表论著70余篇，其中国际权威杂志 50余篇，累计分值 (IF) 达 300分。论文被欧洲泌尿协会（EAU）写入指南、美国国立综合癌症网络(NCCN)写入指南，2017年AJCC-TNM指南分期依据我们的文章重新制定了N分期，从新制定了世界范围内的行业标准。第三版《吴阶平泌尿外科学》阴茎癌章节主编。《Urologic Oncology: Seminars and Original Investigations》、《World Journal of Surgical Oncology》 杂志审稿人。
研究方向：泌尿系肿瘤基础和转化研究
代表性论文（近五年）
- Xingliang Tan, Zhicheng Liu, Taonong Cai, Yanjun Wang, Zhiming Wua, Zike Qin, Zhiyong Li, Zhenhua Liu, Gangjun Yuan, Qianghua Zhou, Kai Yao. Prognostic Significance of HER2 in Patients with Bacillus Calmette-Guérin Exposed Non-muscle-invasive Bladder Cancer. European Urology Oncology,2023 Article in press. JCR Q1 （IF 8.2）
- Xingliang Tan, Yanjun Wang, Zhiming Wu, Qianghua Zhou, Yi Tang, Zhicheng Liu, Gangjun Yuan, Sihao Luo, Yuantao Zou , Shengjie Guo, Na Han, Kai Yao*. The Role of Her-2 in Penile Squamous Cell Carcinoma Progression and Cisplatin Chemoresistance and Potential for Antibody-Drug Conjugate-Based Therapy. European Journal of Cancer, 2023,194:113360. JCR Q1 （IF 8.4）
- Qianghua Zhou, Xu Chen, Kai Yao* (contributed equally to this work), Yangjie Zhang, Haixia He, Hao Huang, Hao Chen,Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li,Tianxin Lin, Hai Huang. TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32‑mediated ubiquitination. Journal of Experimental & Clinical Cancer Research, (2023) 42:195. JCR Q1 （IF 11.3）
- Xingliang Tan#, Dong Chen#, Shengjie Guo#, Yanjun Wang, Yuantao Zou, Fangjian Zhou, Zike Qin, Zhuowei Liu, Yun Cao, Chunhua Lin,, Gangjun Yuan, Kai Yao*. Molecular stratification by BCL2A1 and AIM2 provides additional prognostic value in penile squamous cell carcinoma. Theranostics 2021; 11(3): 1364-76. （IF 11.556）
- Xingliang Tan, Zhenhua Liu, Yanjun Wang, Zhingming Wu, Yuantao Zou, Sihao Luo, Yi Tang, Dong Chen, Gangjun Yuan, Kai Yao*. MiR-138-5p-mediated HOXD11 promotes cell invasion and metastasis by activating the FN1/MMP2/MMP9 pathway and predicts poor prognosis in penile squamous cell carcinoma. Cell Death & Disease, Online ahead of print. （IF 9.685）
Qiang-hua Zhou*, Kai-wen Li*, Yi-ming Lai*, Kai Yao*(contributed equally to this work), Qiong Wang, Wen-li Cai, Yao Wei, Xing-xing Zang, Ke-wei Xu, Jian Huang, Hai Huang.B7 score and T cell infiltration stratify immune status in prostate cancer. Journal for ImmunoTherapy of Cancer 2021. Online ahead of print. （IF 13.751）
- Leiwen Fu, Tian Tian, Kai Yao* (contributed equally to this work), Xiang-Feng Chen, Ganfeng Luo, Yanxiao Gao, Yi-Fan Lin, Yuewei Zhan, Christopher K Fairley, Andrew Grulich, Huachun Zou. Global Pattern and Trends in Penile Cancer Incidence:Population-Based Study. JMIR Public Health and Surveillance 2022 (8), 6, e34874. （IF 14.557）
- Xingliang Tan , Gangjun Yuan , Yanjun Wang, Yuantao Zou, Sihao Luo, Hui Han, Zike Qin , Zhuowei Liu, Fangjian Zhou, Yanling Liu, Kai Yao*. RAB20 Promotes Proliferation via G2/M Phase through the Chk1/cdc25c/cdc2-cyclinB1 Pathway in Penile Squamous Cell Carcinoma. Cancers 2022, 14, 1106. （IF 6.639）
- Kai Yao*, Chen Yue, Yunlin Ye, Dong Chen, Han Hui, Zaishang Li, Zhuowei Liu, Zike Qin, Yonghong Li, Fangjian Zhou*. Lymph Node Mapping in Penile Cancer Patients Undergoing Pelvic Lymph Node Dissection. Journal of Urology 2021；205( 1):145-151. （IF 7.45）
主持的科研基金项目
- 国家自然科学基金（81302224）：CK2 催化亚单位调控AR 促进前列腺癌激素抵抗性进展机制研究
- 中山大学肿瘤防治中心临床医学科学家培养计划（14zxqk08）：人乳头状瘤病毒-16在阴茎肿瘤发生及进展机制中的作用研究
广东省自然科学基金面上项目两项： HOXD11调控STAT3介导Wnt/β-catenin通路在阴茎癌上皮间质转化的机制研究 ； RAB20介导Chk1/cdc25c/cdc2-cyclinB1通路调控G2/M周期检查点促进阴茎癌进展的机制研究
