临床专家

张玉晶

职务:医院淋巴瘤、胃癌、胰胆肿瘤单病种MDT专家会诊组成员,肿瘤放疗专业主诊教授
职称:主任医师,博士生导师

专长

淋巴瘤、胃癌、胰腺癌、胆管癌和乳腺癌等肿瘤的放射治疗及综合治疗。

一、基本情况

职称:主任医师、博士生导师 

专家门诊时间: 周一下午(越秀特需),周三下午(黄埔专家门诊),周四上午(越秀专家门诊)

专业特长:淋巴瘤、胃癌、胰腺癌、胆管癌和乳腺癌等肿瘤的放射治疗及综合治疗。

1. 对各型恶性淋巴瘤,包括结外鼻型NK/T细胞淋巴瘤以及淋巴结、韦氏环、胃肠、眼眶、颅脑、骨等部位原发淋巴瘤的放射治疗有较丰富的经验,在病例数和疗效方面均位于业内先进水平,有多篇研究成果进入著名的NCCN淋巴瘤诊疗指南;

2. 在胃癌的围手术期放化疗、不可手术局部晚期胃癌的根治性放化疗、局部区域复发胃癌的挽救放化疗或免疫联合放化疗方面积累了丰富的经验。参编历年的《中国临床肿瘤学会(CSCO)胃癌诊疗指南》,主持制订中山大学胃癌术前放化疗5010研究(Neo-CRAG)的放疗靶区模板和放化疗方案,参与编制国内首部《中国胃癌放疗指南》(2020版)。

3. 采用国际先进的磁共振加速器、TOMO等新型加速器治疗设备,开展胰腺癌、胆管癌、肝转移癌的调强放疗和体部立体定向放疗(SBRT),改进磁共振/笔形束CT/扇形束CT等影像引导下IGRT的放射治疗精度,大辐提高了疗效。

 

二、教育及工作经历

2002-至今  中山大学肿瘤防治中心放疗科 主治医师、副主任医师、主任医师(2010-),其间

2017.12   美国加州希望之城国家医学中心放射肿瘤科 短期访问学者

2010-2011  新疆医科大学肿瘤医院 放疗科副主任、援疆专家

2008-2009  Baylor医学院/得克萨斯儿童癌症中心 博士后研究助理

2007-2008  得克萨斯大学M.D.安德森癌症中心 访问学者

1999-2002  中国协和医科大学/中国医学科学院肿瘤医院放射肿瘤学 博士研究生

1995-1999  山东大学齐鲁医院肿瘤中心放疗科 住院医师、主治医师

1992-1995  山东医科大学普外科专业 硕士研究生

1986-1992  山东医科大学临床医学六年制英语医学班

 

三、学术兼职

中国抗癌协会淋巴瘤专业委员会 委员

中国老年保健协会淋巴瘤专业委员会 常务委员

国家肿瘤质控中心胃癌质控专家委员会 委员

中国临床肿瘤学会(CSCO)胃癌专家委员会 委员

中国临床肿瘤学会(CSCO)原发性胃癌诊疗指南编写组 成员

中国抗癌协会肿瘤放射治疗专业委员会胃癌学组 副组长

中华医学会放射肿瘤治疗学分会胃肠学组 委员

中华医学会放射肿瘤治疗学分会淋巴瘤乳腺学组 委员

中国医师协会放射肿瘤治疗医师分会胃肠学组 委员

中国医师协会放射肿瘤治疗医师分会淋巴瘤学组 委员

中国抗癌协会神经肿瘤专业委员会淋巴瘤学组 委员

中国淋巴瘤协作组(CLCG)学术委员会 委员

国际淋巴瘤放射治疗协作组(ILROG)成员

广州抗癌协会淋巴瘤专业委员会 主任委员

广州抗癌协会脊柱肿瘤专业委员会 副主任委员

广东省医师协会肿瘤多学科诊疗模式工作委员会 副主任委员

广东省抗癌协会淋巴瘤专业委员会 常务委员

广东省医学会肿瘤学分会淋巴瘤学组 常务委员

广东省抗癌协会胆道肿瘤专业委员会 常务委员

《中华放射肿瘤学杂志》编委会通讯编委

 

四、主持科研项目

参与及主持多项医院、大学、省部及国家级科研课题。

 

五、代表性论著

1. 刘媛,谢文跃,李泉,王汉渝,夏云飞,张玉晶*. PD-1抑制剂联合放疗治疗晚期及复发难治性NK/T细胞淋巴瘤疗效[J].  中华放射肿瘤学杂志, 2024, 33(5): 426-431.

2. Zhao R, Shao H, Shi G, Qiu Y, Tang T, Lin Y, Chen S, Huang C, Liao S, Chen J, Fu H, Liu J, Xu B, Liu T, Zhang YJ*, Yang Y*. The role of radiotherapy in patients with refractory Hodgkin's lymphoma after treatment with brentuximab vedotin and/or immune checkpoint inhibitors. J Natl Cancer Cent. 2024 Mar;4(1): 86-92. 

3. Shao H, Li N, Ling YH, Wang JJ, Fang Y, Jing M, Zhou ZW, Zhang YJ*.  Nomogram for predicting pathological response to neoadjuvant treatment in patients with locally advanced gastric cancer: Data from a phase III clinical trial. Cancer Med. 2024 Mar; 13(6): e7122.  

4. Niu S, Li Y, Shao H, Hu J, Wang J, Wang H, Zhang YJ*. Phase 2 Clinical Trial of Simultaneous Boost Intensity Modulated Radiation Therapy with 3 Dose Gradients in Patients with Stage I-II Nasal Type Natural Killer/T-Cell Lymphoma: Long-Term Outcomes of Survival and Quality of Life. Int J Radiat Oncol Biol Phys. 2024 March 1;118(3):770-780.

5. Wang JJ, Shao H, Zhang L, Jing M, Xu WJ, Sun HW*, Zhou ZW, Zhang YJ*. Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clinical trial. Radiat Oncol. 2023 Jun 9;18(1):100. DOI: 10.1186/s13014 -023-02269-6. 

6. 向淼,王汉渝,朱丹,陈烨,王继金,邵晗,夏云飞,张玉晶*. 205例颅内原发弥漫大B细胞淋巴瘤的治疗和预后分析[J].  中华放射肿瘤学杂志, 2023, 32(4): 307-312.

7. Wang JJ, Shao H, Yan J, Jing M, Xu WJ, Sun HW*, Zhou ZW, Zhang YJ*. Neoadjuvant chemoradiotherapy induced lymphopenia in gastric cancer and associations with spleen dosimetry and survival outcomes. Clin Transl Radiat Oncol, 2023 Mar 20; 40:100617.  

8. Sun GY, Wen G, Zhang YJ*, Tang Y, Jing H, Fang H, Wang JY, Zhang J, Zhao XR, Chen SY, Song YW, Jin J, Liu YP, Tang Y, Qi SN, Li N, Chen B, Lu NN, Li YX, Wang SL. Risk Factors to Identify the Indication for Regional Nodal Irradiation in T1-2N1M0 Breast Cancer: A Joint Analysis of 4243 Real-World Cases from Two Institutions. Front Oncol. 2022 Dec 20;12:955381. 

9. Ruan Z, Zhang Y, Quan Q, Jiang J, Wang Q, Zhang YJ*, Peng R*. Pan-Cancer Analysis identifies DDX56 as a Prognostic Biomarker Associated with Immune Infiltration and Drug Sensitivity. Frontiers in Genetics. Front Genet. 2022 Dec 7;13:1004467.  

10. Yang Y, Wang JJ, Zhao RZ, Huang C, Shi GQ, Zheng H, Tang TL, Liao SQ, Chen JH, Shen JZ, Liu TB*, Xu BH*, Zhang YJ*. The value of routine bone marrow examination in patients with extranodal NK/T-cell lymphoma staged with PET/CT[J]. Cancer, 2022 Nov 15;128(22):3943-3950.

11. 李艺敏,张玉晶*,李贻阳,叶煜铭,张跃桐,王继金,王汉渝. 早期结外NK/T细胞淋巴瘤鼻型患者根治性放疗后生存质量分析. 中华放射肿瘤学杂志, 2022, 31(9) : 798-804.

12. 张跃桐,张玉晶*,王继金,邵晗,王汉渝,戴淑琴,黄慧强. 结外NK/T细胞淋巴瘤鼻型患者B症状与EBV-DNA及细胞因子预后价值分析. 中华放射肿瘤学杂志, 2022, 31(8):704-709.

13. 张莉,张玉晶*,王继金,张黎,蔡晓军,宋盈. 胃癌同期放化疗所致血小板减少危险因素分析[J]. 中华放射肿瘤学杂志, 2022,31(2):160-164.

14. 李鼐,张玉晶*,方艺, 张黎,黄劭敏,周志伟. 疗前外周血NE值和LMR对局部进展期胃癌术前治疗后病理反应的预测价值[J]. 中华放射肿瘤学杂志,2021,30(4):363-367.

15. Sun GY, Wen G, Zhang YJ*, Tang Y, Jing H, Wang JY, Zhang JH, Yang Y, Zhao XR, Chen SY, Jin J, Song YW, Liu YP, Fang H, Ren H, Tang Y, Qi SN, Li N, Chen B, Lu NN, Wang SL*, Li YX*. Radiotherapy plays an important role in improving the survival outcome in patients with T1-2N1M0 breast cancer - a joint analysis of 4262 real world cases from two institutions[J]. BMC Cancer, 2020 Nov 26;20(1):1155. 

16. Wang SL, Wen G, Tang Y, Yang Y, Jing H, Wang J, Zhang J, Zhao X, Sun G, Jin J, Song Y, Liu Y, Fang H, Zhang YJ*, Li YX*. Effectiveness of the AJCC 8th edition staging system for selecting patients with T1-2N1 breast cancer for post-mastectomy radiotherapy: a joint analysis of 1986 patients from two institutions. BMC Cancer. 2020 Aug 24;20(1):792.

17.Tang Y, Zhang YJ*, Zhang N*, Shi M, Wen G, Cheng J, Wang HM, Liu M, Wang XH, Guo QS, Wu HF, Ma CY, Jin J, Liu YP, Song YW, Fang H, Ren H, Wang SL, Li YX. Nomogram predicting survival as a selection criterion for postmastectomy radiotherapy in patients with T1 to 2 breast cancer with 1 to 3 positive lymph nodes. Cancer. 2020 Aug 15;126 Suppl 16:3857-3866.

18. Qi SN, Yang Y*, Zhang YJ*, Huang HQ*, Wang Y, He X, Zhang LL, Wu G, Qu BL, Qian LT, Hou XR, Zhang FQ, Qiao XY, Wang H, Li GF, Zhu Y, Cao JZ, Wu JX, Wu T, Zhu SY, Shi M, Xu LM, Yuan ZY, Su H, Song YQ, Zhu J, Hu C, Li YX. Risk-based, response-adapted Therapy for Early-stage Extranodal Nasal-type NK/T-cell Lymphoma in the Modern Chemotherapy Era: A China Lymphoma Collaborative Group (CLCG) Study. Am J Hematol. 2020 Sep;95(9):1047-1056. 

19. 方艺,张玉晶*,李鼐,凌逸虹,周志伟. Lauren分型与局部进展期胃癌术前放化疗后肿瘤病理反应相关性分析[J]. 中华放射肿瘤学杂志,2020,29(5):349-353.

20. Wang HY, Niu SQ, Yang YY, Li YY, Chen HB, Zhang YJ*. Promising clinical outcomes of sequential and "Sandwich" chemotherapy and extended involved-field intensity-modulated radiotherapy in patients with stage IE /IIE extranodal natural killer/T-cell lymphoma.  Cancer Med. 2018 Dec;7(12): 5863-5869.

21. Tong Q, Ouyang SM, Feng LL, Wang HY, Xia YF, Zhang YJ*. Salvage radiotherapy improves survival in patients with locoregionally relapsed stage IE-IIE extranodal natural killer/T-cell lymphoma, nasal type. Ther Clin Risk Manag. 2018 Jun 6;14:1083-1090. 

22. 冯玲玲,张玉晶*,张黎,黄劭敏,周志伟.  胃癌术前放化疗正常组织放射损伤的剂量效应分析. 中华放射肿瘤学杂志, 2018; 27(3): 271-276.

23. Wen G, Wang WH, Zhang YJ*, Niu SQ, Li QW, Li YX*. Management of extramedullary plasmacytoma: role of radiotherapy and prognostic factor analysis in 55 patients. Chin J Cancer Res. 2017 Oct; 29(5): 438-446.

24. 孟凡军,郭建贵,林尤恩,张玉晶*.  71例原发颅内中枢神经系统DLBCL预后分析.  中华放射肿瘤学杂志.  2017; 26 (8): 909-913. 

25. Huang YH, Rao HL, Yan SM, Wang F, Wu QN, Feng YF, Zhang YJ*. Serum EBV EA-IgA and VCA-IgA antibodies can be used for risk group stratification and prognostic prediction in extranodal NK/T cell lymphoma: 24-year experience at a single institution. Ann Hematol. 2017 Aug; 96(8):1331-1342.

26. Xu S, Feng L, Chen Y, Sun Y, Lu Y, Huang S, Fu Y, Zheng R*, Zhang YJ*, Zhang R*. Consistency mapping of 16 lymph node stations in gastric cancer by CT-based vessel-guided delineation of 255 patients. Oncotarget. 2017 Jun 20; 8(25): 41465- 41473.  

27. Niu SQ, Wen G, Ren YF, Li YY, Feng LL, Wang CT, Huang XB, Wen BX, Zhang YJ*. Predictive Value of Primary Tumor Site for Loco-regional Recurrence in Early Breast Cancer Patients with One to Three Positive Axillary Lymphadenophy. J Cancer. 2017; 8(12): 2394-2400.

28. Wang QX, Li SH, Ji BY, Wang HY, Li YY, Feng LL, Chen K*, Xia YF, Zhang YJ*. Lymphocyte/Monocyte Ratio is a Novel Predictor for Early Stage Extranodal Natural Killer/T-cell Lymphoma, Nasal Type. J Cancer. 2017 Apr 8; 8(6): 1030-1037.

29. Li YY, Lin HQ, Zhang LL, Feng LL, Niu SQ, Wang HY, Zhang YJ*, Wang XC*. Intensity-modulated radiotherapy has superior outcomes to three-dimensional conformal radiotherapy in patients with stage IE-IIE extranodal nasal-type natural killer/T-cell lymphomatype nature killer/T-cell lymphoma. Oncotarget. 2017 Mar 11;8(36): 60504-60513.  

30. Li YY, Feng LL, Niu SQ, Wang HY, Zhang LL, Wang L, Xia ZJ, Huang HQ,  Xia YF, Zhang YJ*, Wang XC*.  Radiotherapy improves survival in early stage extranodal natural killer/T cell lymphoma patients receiving asparaginase-based chemotherapy. Oncotarget. 2017 Feb 14; 8(7): 11480-11488. 

31. 童琴,罗燕容,张玉晶*,冯玲玲,李贻阳,王汉瑜,夏云飞,艾小红.  局部区域复发的结外鼻型NK/T细胞淋巴瘤挽救治疗的疗效和预后分析. 中华放射肿瘤学杂志.  2017;26 (1):45-49.

32. 冯玲玲,张玉晶*,李绮雯,李贻阳,王俏镟,曾智帆,周志伟.  不能切除和复发的局部进展期胃癌放射治疗的疗效分析. 中华放射肿瘤学杂志. 2016; 25 (11): 1209-1213.

33. Wang L, Bi XW, Xia ZJ, Huang HQ, Jiang WQ, Zhang YJ*. Radiation dose reduction for patients with extranodal NK/T-cell lymphoma with complete response after initial induction chemotherapy. Onco Targets Ther. 2016 Sep 26; 9: 5875-5881.

34. Wen G, Zhang JS, Zhang YJ*, Zhu YJ, Huang XB, Guan XX.   Predictive Value of Molecular Subtyping for Locoregional Recurrence in Early-Stage Breast Cancer with N1 without Postmastectomy Radiotherapy. J Breast Cancer. 2016 Jun; 19(2): 176-184.  

35. 温戈,张玉晶*,张金山,牛绍清,李贻阳,冯玲玲,夏云飞.  早期肺原发黏膜相关淋巴组织淋巴瘤的预后分析及文献回顾. 中华放射肿瘤学杂志.  2016; 25 (7): 713-717. 

36. Niu SQ, Yang Y, Li YY, Wen G, Wang L, Li ZM, Wang HY, Zhang LL, Xia YF, Zhang YJ*. Primary site and regional lymph node involvement are independent prognostic factors for early-stage extranodal nasal-type natural killer/T cell lymphoma. Chin J Cancer. 2016 Apr 4; 35(1): 34.  

37. 李贻阳,牛绍清,温戈,王俏镟,王汉渝,冯玲玲,夏云飞,张玉晶*.  基于GELOX方案诱导化疗的I-II期结外鼻型NK/T细胞淋巴瘤根治性放疗的预后分析. 中华放射肿瘤学杂志.  2016; 25 (2): 140-145.

38. Wang L, Xia ZJ, Lu Y, Wang QX, Niu SQ, Huang HQ, Zhang YJ*.  A modified-international prognostic index including pretreatment hemoglobin level for early stage extranodal NK/T cell lymphoma. Leuk Lymphoma, 2015 Nov; 56(11): 3038-44.

39. Wang L, Wang H, Wang JH, Xia ZJ, Lu Y, Huang HQ, Jiang WQ,  Zhang YJ*.   Post-treatment plasma EBV-DNA positivity predicts early relapse and poor prognosis for patients with extranodal NK/T cell lymphoma in the era of asparaginase.  Oncotarget. 2015 Oct; 6(30):30317-26. 

40. Wang L, Wang Z, Xia ZJ, Lu Y, Huang HQ, Zhang YJ*. CD56 negative extranodal NK/T cell lymphoma should be regarded as a distinct subtype with poor prognosis. Tumour Biol. 2015 Sep; 36(10):7717-23.

41. 牛绍清,温戈,张玉晶*,王成涛,李贻阳,黄晓波,管迅行,文碧秀.  早期乳腺癌原发象限对根治术后1~3个腋窝淋巴结转移患者预后预测价值探讨.  中华放射肿瘤学杂志.  2015; 24 (5): 506-510. 

42. Li QW, Li W, Wang L, Wang WD, Niu SQ, Bi XW, Wang HY, Zhang YJ*. Consolidation radiotherapy in stage IE-IIE, non-bulky primary gastric diffuse large B-cell lymphoma with post-chemotherapy complete remission. PLoS One. 2015, Jul 20; 10(7): e0133469.  

43. 牛绍清,张玉晶*,温戈,李贻阳,冯玲玲,王汉渝,文碧秀.  早期原发鼻腔NK/T细胞淋巴瘤局部扩大野IMRT前瞻性II期研究的初步结果. 中华放射肿瘤学杂志.  2015; 24 (4): 377-381.

44. Yang Y, Zhang YJ*, Zhu Y, Cao JZ, Yuan ZY, Xu LM, Wu JX, Wang W, Wu T, Lu B, Zhu SY, Qian LT, Zhang FQ, Hou XR, Liu QF, Li YX.  Prognostic nomogram for overall survival in previously untreated patients with extranodal nk/t-cell lymphoma, nasal-type: a multicenter study. Leukemia. 2015 Jul; 29(7):1571-7.  

45. Li QW, Niu SQ, Wang HY, Wen G, Li YY, Xia YF, Zhang YJ*.  Radiotherapy alone is associated with improved outcomes over surgery in the management of solitary plasmacytoma. Asian Pac J Cancer Prev. 2015; 16(9):3741-5. 

46. Wang L, Xia ZJ, Lu Y, Zhang YJ*.  Prophylactic cervical lymph node irradiation provides no benefit for patients of stage IE extranodal natural killer/T cell lymphoma, nasal type.  Med Oncol. 2015 Jan; 32(1):320. 

 

六、获奖及荣誉

2011.9  香港乳腺癌学术大会 优秀论文奖

2017.11 中国医师协会MDT百城行最强胃来战队总决赛 冠军队(成员)

2018.1  中华医学科技奖一等奖,项目名称“非霍奇金淋巴瘤的个体化诊治策略的创新和应用”, 团队成员

2018.9  中国临床肿瘤学会(CSCO)胃癌MDT风采秀总决赛 冠军队(成员)

2019.1  入选“广东医院最强科室之实力中青年医生推荐(广州)”榜单

2019.9  美国放射肿瘤学会(ASTRO)年会学术论文奖: Resident Recognition Awards/Resident Mini-oral Recognition Award(指导老师) 

2020.7  中国抗癌协会科技奖一等奖“中国恶性淋巴瘤创新基础与临床应用系列研究”项目,团队成员

2023.1  广东省医学科技二等奖“T细胞淋巴瘤精准诊疗体系建立与推广应用”,团队成员

2024.6  广东省科学技术奖科技进步奖一等奖“T细胞淋巴瘤精准诊疗策略创新与临床应用”,团队成员

 

 

 

 

更新时间:2024.08.28