黄慧琳

黄慧琳博士2012年于中山大学获得博士学位。随后，在美国西北大学Chonghui Cheng教授和辛辛那提大学Jianjun Chen教授课题组进行博士后训练。回国前担任美国希望之城国家医学中心研究助理教授。2020年通过国家海外高层次人才计划和中山大学“百人计划”引进回国。目前担任中山大学肿瘤防治中心研究员，华南恶性肿瘤防治全国重点实验室独立PI，博士生导师。

黄慧琳博士长期专注于肿瘤RNA表观遗传学的科学研究，取得多项原创性成果，包括揭示RNA m6A甲基化的生成决定机制（Nature, 2019.）、发现一类全新的m6A 读码器和m6A修饰的新功能（Nature Cell Biology, 2018.）、阐明m6A修饰在正常造血分化及急性髓系白血病中的作用（Cell Stem Cell, 2018; Cancer Cell, 2020.）。迄今为止，黄慧琳博士共发表SCI论文40余篇，引用超过9000次，以通讯或第一作者身份在Nature、Nature Cell Biology（2篇）、Cell Stem Cell、Cancer cell（2篇）和Nature Reviews Clinical Oncology等国际高水平期刊发表论文。担任广州精准医学应用学会委员，美国血液学会会员，中国细胞生物学学会会员。担任Nature Cell Biology, National Science Review、Nature Communications和Science Advance等期刊的审稿人。

研究方向：

课题组研究方向为肿瘤中RNA修饰的功能机制和干预：

（1）在白血病和多种实体瘤中采用表观转录组测序系统挖掘RNA修饰相关的生物标志物；

（2）鉴定新型的RNA修饰调控蛋白，并阐明其在肿瘤代谢、干性维持和免疫响应等方面的生物学功能。

（3）以RNA修饰相关蛋白为靶点开发小分子抑制剂和抗肿瘤疗法。

主持项目：

国家自然科学基金，面上项目，82470161

广州市科技技术局，科技菁英“领航”项目，2024A04J6321

国家自然科学基金，面上项目，82173058

广东省基础与应用基础研究基金，面上项目，2021A1515010425

代表性论文：

1. Subo Zhang*, Feng Huang*, Yushuai Wang*, Yifei Long*, Yuanpei Li, Yalin Kang, Weiwei Gao, Xiuxin Zhang, Yueting Wen, Yun Wang, Lili Pan, Youmei Xia, Zhoutian Yang, Ying Yang, Hongjie Mo, Baiqing Li, Jiacheng Hu, Yunda Song, Shilin Zhang, Shenghua Dong, Xiao Du, Yingmin Li, Yadi Liu, Wenting Liao, Yijun Gao, Yaojun Zhang, Hongming Chen, Yang Liang, Jianjun Chen, Hengyou Weng#, Huilin Huang#. NAT10-mediated mRNA N4-acetylcytidine Reprograms Serine Metabolism to Drive Leukaemogenesis and Stemness in Acute Myeloid Leukaemia，Nature Cell Biology，2024, accepted.
2. Yi Zhou*, Yaxin Zhang*, Mingzhou Li*, Tian Ming*, Chao Zhang, Chengmei Huang, Jiexi Li, Fengtian Li, Huali Li, Enen Zhao, Feng Shu, Lingtao Liu, Xingyan Pan, Yijun Gao, Lin Tian, Libing Song#, Huilin Huang#, Wenting Lao#. Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry. Science Immunology, 2024, 9(100): eado8758.
3. Yixiao Zhu*, Chengmei Huang*, Chao Zhang*, Yi Zhou*, Enen Zhao, Yaxin Zhang, Xingyan Pan, Huilin Huang#, Wenting Liao#, Xin Wang#. LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target directed miRNA degradation. Nature Communications, 2023, 14(1): 8141.
4. Xiaolan Deng*#, Ying Qing* , David Horne, Huilin Huang#, Jianjun Chen#, The roles and implications of RNA m6A modification in cancer. Nature Reviews Clinical Oncology. 2023, 20(8): 507-526.
5. Hengyou Weng*#, Feng Huang*, Zhaojin Yu*, Zhenhua Chen*, Emily Prince, Yalin Kang, Keren Zhou, Wei Li, Jiacheng Hu, Chen Fu, Tursunjan Aziz, Hongzhi Li, Jingwen Li, Ying Yang, Li Han, Subo Zhang, Yuelong Ma, Mingli Sun, Huizhe Wu, Zheng Zhang, Mark Wunderlich, Sean Robinson, Daniel Braas, Johanna ten Hoeve, Bin Zhang, Guido Marcucci, James C Mulloy, Keda Zhou, Hong-Fang Tao, Xiaolan Deng, David Horne, Minjie Wei#, Huilin Huang#, Jianjun Chen#. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell, 2022, 40(12): 1566-1582.
6. Huilin Huang*, Hengyou Weng*, Jianjun Chen#. M6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer. Cancer Cell, 2020, 37(3): 270–288.
7. Huilin Huang*, Hengyou Weng*, Keren Zhou*, Tong Wu*, Boxuan Simen Zhao*, Mingli Sun, Zhenhua Chen, Xiaolan Deng, Gang Xiao, Franziska Auer, Lars Klemm, Huizhe Wu, Zhixiang Zuo, Xi Qin, Yunzhu Dong, Yile Zhou, Hanjun Qin, Shu Tao, Juan Du, Jun Liu, Zhike Lu, Hang Yin, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Wenju Sun, Rui Su, Lei Dong, Chao Shen, Chenying Li, Ying Qing, Xi Jiang, Xiwei Wu, Miao Sun, Jun-Lin Guan, Lianghu Qu, Minjie Wei, Markus Müschen, Gang Huang#, Chuan He#, Jianhua Yang#, and Jianjun Chen#. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature, 2019, 567(7748): 414–419.
8. Huilin Huang*, Hengyou Weng*, Wenju Sun*, Xi Qin*, Hailing Shi*, Huizhe Wu, Boxuan Simen Zhao, Ana Mesquita, Chang Liu, Celvie L. Yuan, Yueh-Chiang Hu, Stefan Hüttelmaier, Jennifer R. Skibbe, Rui Su, Xiaolan Deng, Lei Dong, Miao Sun, Chenying Li, Sigrid Nachtergaele, Yungui Wang, Chao Hu, Kyle Ferchen, Kenneth D. Greis, Xi Jiang, Minjie Wei, Lianghu Qu, Jun-Lin Guan, Chuan He#, Jianhua Yang#, Jianjun Chen#. Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation. Nature Cell Biology, 2018, 20(3): 285–295.
9. Hengyou Weng*, Huilin Huang*, Huizhe Wu*, Xi Qin*, Boxuan Simen Zhao*, Lei Dong*, Hailing Shi, Jennifer Skibbe, Chao Shen, Chao Hu, Yue Sheng, Yungui Wang, Mark Wunderlich, Bin Zhang, Louis C Dore, Rui Su, Xiaolan Deng, Kyle Ferchen, Chenying Li, Miao Sun, Zhike Lu, Xi Jiang, Guido Marcucci, James Mulloy, Jianhua Yang, Zhijian Qian, Minjie Wei#, Chuan He#, Jianjun Chen#. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell, 2018, 22(2): 191–205.