科研学者

李焱

职称：博士，研究员，博士生导师

专长

肿瘤发生和肿瘤生物学行为；肿瘤转移；肿瘤微环境

职称：博士，研究员，博士生导师

专长：肿瘤发生和肿瘤生物学行为；肿瘤转移；肿瘤微环境

 

博士，研究员, 博士生导师, 中山大学肿瘤防治中心, 华南肿瘤学国家重点实验室工作，从事肿瘤的发病机制和防治研究。主持多项基金包括：国家自然科学基金（82072604，81871903，81672357，81472255，81172338和30700820），广东省自然科学基金，广东省科技计划等。并作为骨干参与多项科研项目如国家重点研发计划、国家科技重大专项等研究。作为参与者获得了高等学校自然科学奖一等奖，中华医学科技奖二等奖和广东省科学技术奖一等奖等，并获得“广东省杰出青年医学人才”称号（2018）。发表文章80余篇，包括在国际知名杂志如Gastroenterology, Cancer Res，Oncogene等发表第一或通讯作者文章多篇。是广东省自然医学研究会-干细胞与中医再生医学专业委员会的常务委员。担任热带医学杂志、World Journal of Gastroenterology等杂志的编委会成员以及Cancer letters, Cell Death & Disease, International Journal of Cancer, British Journal of Cancer, Cancer Medicine和中国医学科学院学报等杂志的审稿人。

 

学科：1）肿瘤学  2）生物化学与分子生物学

专业特长和研究方向：肿瘤发生和肿瘤生物学行为；肿瘤转移；肿瘤微环境

 

联系方式：liyan@sysucc.org.cn;   liy6@mail.sysu.edu.cn

通讯地址：广州市东风东路651号　中山大学肿瘤防治中心实验研究部　 510060

 

代表性研究成果（*，通讯作者）：

  1. Zheng Y, Wu J, Deng R, Lin C, Huang Y, Yang X, Wang C, Yang M, He Y, Lu J, Su X, Yan Q, Zhu Y, Guan X, Li Y*, Yun J*. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.
  2. Suo D, Wang Z, Li L, Chen Q, Zeng T, Liu R, Yun J, Guan XY*, Li Y*. HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis. Oncogene. 2020 Aug;39(32):5441-5454.
  3. Suo D#, Wang L#, Zeng T, Zhang H, Li L, Liu J, Yun J, Guan XY*, Li Y*. NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Oncogenesis. 2020 Aug 24;9(8):75.
  4. Zeng T#, Tang Z#, Liang L, Suo D, Li L, Li J, Yuan Y, Guan XY*, Li Y*. PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB. Mol Oncol. 2020 Dec;14(12):3184-3197.
  5. Zhan YT#, Li L#, Zeng TT, Zhou NN, Guan XY*, Li Y*. SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma. Aging (Albany NY). 2020 Dec 3;13(1):537-554.
  6. Li M, Wang L, Zhan Y, Zeng T, Zhang X, Guan XY*, Li Y*. Membrane Metalloendopeptidase (MME) Suppresses Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) by Inhibiting FAK-RhoA Signaling Axis. Am J Pathol. 2019 Jul;189(7):1462-1472.
  7. Zheng YL#, Li L#, Jia YX, Zhang BZ, Li JC, Zhu YH, Li MQ, He JZ, Zeng TT, Ban XJ, Yuan YF, Li Y*, Guan XY*. LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway. Theranostics. 2019 Jan 24;9(3):796-810.
  8. Li Y*, Lin S, Li L, Tang Z, Hu Y, Ban X, Zeng T, Zhou Y, Zhu YH, Gao S, Deng W, Zhang X, Xie D, Yuan Y, Huang P, Li J, Cai Z, Guan XY*. PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration and reprogramming glucose metabolism. Cancer Res. 2018 Aug 15;78(16):4471-4481.
  9. Zhang B, Zhang Z, Li L, Qin YR, Liu H, Jiang C, Zeng TT, Li MQ, Xie D, Li Y*, Guan XY*, Zhu YH*. TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling. Nat Commun. 2018 Apr 12;9(1):1423.
  10. Wang L, Li M, Zhan Y, Ban X, Zeng T, Zhu Y, Yun J, Guan XY*, Li Y*. Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients. Mol Carcinog. 2018 Jul;57(7):886-895.
  11. Zhou Y, Wang L, Ban X, Zeng T, Zhu Y, Li M, Guan XY*, Li Y*. DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene. 2018 Feb 22;37(8):1086-1094.
  12. Huang PY, Zeng TT, Ban X, Li MQ, Zhang BZ, Zhu YH, Hua WF, Mai HQ, Zhang L, Guan XY*, Li Y*. Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy. BMC Cancer. 2016 Aug 22;16:669.
  13. Li H, Zhang J, Chen SW, Liu LL, Li L, Gao F, Zhuang SM, Wang LP, Li Y*, Song M*. Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer. J Transl Med. 2015 Jun 21;13(1):198.
  14. Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2014 Jun;146(7):1701-1713.
  15. Chen K, Li Y*, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma. PLoS One. 2013 Jul 24;8(7):e68838.
  16. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin Y, Guan XY*.  Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma. PLoS One. 2013;8(4):e60027. 
  17. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res. 2011 Oct 1; 71(19):6106-15.
  18. Li Y, Nie CJ, Hu L, Qin YR, Liu HB, Zeng TT, Chen LL, Fu L, Deng W, Chen SP, Jia WH, Zhang CY, Xie D, Guan XY.  Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers.  Cancer Res.  2010 Jul 15.70(14)：5695-705.
  19. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther. 2008 Aug;19(8):827-39.

 

 

更新时间：2023年1月9日