Present title (s) in SYSUCC

　　Associate Professor

 
Contact Information

  Department of Critical Care Medicine

  Sun Yat-sen University Cancer Center

  State Key Laboratory of Oncology in Southern China

  Guangzhou (510060), China

  E-mail: louning@sysucc.org.cn

  Tel: +86-20-8734 3630 

Research direction

1.   Onco-cardiology and onco-cardiological prevention

2.   Atherosclerosis prevention

3.   Hypercoagulation  prevention

4.   Postoperative complications (cardiovascular and renal) prevention

Education

1987 - 1993 Undergraduate Education for MD
    M.D, Medicine, First Military Medical University, Guangzhou, China 

1993 - 1996 Postgraduate Training
    MSc degree, Biochemistry and Molecular Biology, First Military Medical University, Guangzhou, China. 

1998 - 2001 Graduate Education for PHD
  Ph.D degree, Cardiology,  Zhong Nan University Xiang Ya Medical College, Changsha, China. 

Professional Appointment(s)

1996 - 1998
  　Teaching assistant, Department of Pharmacology, First Military Medical University 

2001 - 2001
　　Physician in Charge, Department of Cardiology, Second Hospital, Guangzhou Medical College  

2001 - 2004

Postdoctorate and Physician in Charge, Department of Nephrology, First Hospital, Sun Yat-Sen University  

2004 - 2006
　　Physician in Charge,  Department of Critical Care Medicine, Sun Yat-Sen University Cancer Center  

2006 - Present
　　Associate Professor, Department of Critical Care Medicine, Sun Yat-Sen University Cancer Center

Grant(s)

Current Grant Support

1. Title: Mechanisms of Coriolus Versicolor polysaccharide B in preventing atherosclerosis based on response-to-retention hypothesis

Funding source:  Guangdong Provincial Natural Science Foundation.

Role: PI

Amount: RMB50, 000

Duration: 2009-2010

2.  Title: Effects of Coriolus Versicolor polysaccharide B in preventing hypercoagulation of cancer based on heparanase coagulation mechanisms

Funding source: Guangdong Provincial Science and Technology Program

Role: PI

Amount: RMB 40,000

Duration: 2011-2013

Past Grant Support

1. Title: Regulations of glutathione peroxidase by polysaccharide krestin in macrophages

Funding source: National Natural Science Foundation

Role: PI

Amount: RMB 100,000

Duration: 1997-1999

2. Title: Effects of Coriolus Versicolor polysaccharide B in preventing radioactive pulmonary fibrosis

Funding source: Guangdong Provincial Science and Technology Program

Role: PI

Amount: RMB 30,000

Duration: 2004-2006

Selected publications

1. Lou N, Wang DF, Fang Y, Ma G. Effects of Coriolus Versicolor polysaccharides B on macrophage surface chondroitin sulfate-proteoglycans binding oxidized low density lipoprotein. Chinese Pharmacological Bulletin, 2009, 25:1181-4

2.  Lou N, Ma G, Wang DF, Fang Y. Effect of Coriolus Versicolor polysaccharides B on osteopontin mRNA expression in macrophages induced by angiotensin Ⅱ. Chinese Pharmacological Bulletin, 2008, 24:1284-8.

3.   Lou N, Ma G, Wang DF, Fang Y. Regulations of Coriolus Versicolor polysaccharides B inhibiting monocyte chemoattractant protein-1 mRNA expression induced by Ox-LDL in macrophages. Chinese Journal of Pathophysiology, 2008, 24:1436-8. 

4.   Lou N, Ma G, Wang DF, Zhu ZW, Su QG, Fang Y. Effects of Coriolus Versicolor polysaccharides B on membrane glycosaminoglycans and cellular glutathione changes in RAW264.7 macrophages exposed to angiotensin Ⅱ. Journal of Southern Medical University, 2007, 27:1824-6.

5.   Lou N, Yu XQ, Zhu SL, Zheng XH, Dong XQ. Angiotensin Ⅱ stimulates p38MAPK phosphorylation and proliferation of macrophage cell line. Chinese Journal of Immunology, 2005, 21:416-20.

6.  Lou N, Yu XQ, Zhu SL, Zheng XH, Dong XQ, Li XY. Angiotensin Ⅱ up-regulates osteopontin mRNA expression of RAW264.7 macrophages via p38MAPK signaling. National Medical Journal of China, 2004, 84:1283-7.

7.   Lou N, Yu XQ, Zhu SL, Dong XQ. Glutathione depletion inhibits angiotensin Ⅱ-induced activation of c-Jun/ATF-2 and NF-κB in cultured macrophages. Chinese Journal of Pathophysiology, 2004, 20:1745-9.