王辉云，医学博士，中山大学“百人计划”引进人才、教授、博士生导师，现任华南肿瘤学国家重点实验室肿瘤生物组学与标志物课题组组长。1982年衡阳医学院医疗专业毕业，获医学学士学位；1990年和1997年于中山医科大学分别获得医学硕士和医学博士学位。1990年硕士研究生毕业后留在中山医科大学肿瘤研究所工作，1997任肿瘤病理研究室副主任；1999年到美国进行博士后研究，2002年晋升为美国新泽西医科牙科大学助理教授；2006年获聘中山大学研究员；2012年获聘美国Rutgers大学客座副教授。从事肿瘤基础、应用基础与转化研究30多年，早期参与我国鼻咽癌攻关课题和肝癌的预防、发病过程及分子机制等方面的研究；1996和1998年获得二项国家自然基金面上项目和一项广东省自然科学基金课题，同时作为我国鼻咽癌重大项目主要组织和实施者，成功地将鼻咽癌易感基因定位于4号染色体，结果发表于《Nature Genetics》上。1999年出国留学，从事生物芯片和肿瘤的研究，首创“千重PCR”及其芯片，结果发表在国际基因组研究的核心期刊《Genome Research》上。2007年引进回国后，建立了生物芯片研究室，制作了DNA和蛋白等各种芯片，成为国内第一个能制作多种生物芯片的大学实验室。以此平台为基础，不仅获得了“863计划”和国自然等十余个课题，而且在多个高水平杂志上发表了文章，取得了多个重要成果。迄今为止，在Nature Genetics, Lancet Oncology, Cancer Cell, Genome Research, Hepatology, PNAS, Nature Communication, Journal of Hepatology, Clinical Cancer Research, Molecular Cancer等杂志发表120多篇学术论文，获得和主持20多个研究课题，培养硕士、博士和博士后30余人，申请10个专利（3个已授权），获得9个学术成就和科技成果奖。
课题组成员
研究助理：买世娟副研究员；
技术人员：张美殷主管技师；
博士后：孙朝跃（2019入站）、王嘉惠（2019入站）
博士生：张珊珊（16级直博生）、任倩楠（17级直博生）、李少龙（18级）、王悦宁（19级直博生）、殷玉婷（20级）。
课题组在研课题：
1) 2019年国家自然科学基金面上项目：《环状RNA-circQDPR在肝癌中的临床意义及作用机制的研究》。项目批准号：81972640, 研究时间：2020.01 – 2023.12，资助额：¥ 55.0万人民币。
2) 2017年国家自然科学基金面上项目：《GPAT3在肝癌发生发展中的作用及机制研究》。项目批准号：81772991, 研究时间：2018.01 – 2021.12，资助额：¥ 55.0万人民币。
3) 2017年国家自然科学基金面上项目 《NMD相关基因在鼻咽癌发生发展中的作用及机制研究。项目批准号：81772884, 研究时间：2018.01 – 2021.12，资助额：¥ 52.0万人民币。
4) 2017年国家自然科学基金重点项目：《mTOR在肿瘤中对染色质重塑的调控机制及其意义》。项目批准号：81730081, 研究时间：2018.01 – 2022.12，资助额：¥ 290.0万人民币。
5) 2016年国家自然科学基金-海外及港澳学者合作研究基金延续项目：《非编码RNA在乳腺癌转移中的作用与临床意义研究》，项目批准号：81629004，研究时间：2017.01 — 2020.12，资助总额：¥ 216.0万人民币。
专利申请
1） 王辉云、龙潇冉、张美殷、买世娟。4-LncRNA分子标签在肺癌预后评估中的应用。中国国家专利局，专利申请号：201811307081.4，申请日期：2018年11月05日。
2） 王辉云、徐睿、张美殷。4-LncRNA分子标签用于肝癌预后的试剂盒。中国国家专利局，专利申请号：201810503020.9，申请日期：2018年
3） 王辉云、龙潇冉、张美殷。全血88-microRNA标记物作为肝脏慢性疾病诊断靶标的应用。中国国家专利局，专利申请号：CN201710378359.6，申请日期：2017年05月25日。
4） 张纪斌 、王辉云、林钊、李伟琴、罗景燕、赖炳权。一种扩增BRCA1/2基因的多重PCR引物及一种多重PCR引物的设计方法。中国国家专利局，专利申请号：CN201610737156.7，申请日期：2016年08月26日
5） 郑晓峰 、王辉云、 李晓星、江超。一种治疗癌症的新联合用药方案。中国国家专利局，专利申请号：CN201610301148.8；申请日期：2016年05月09日
6） 王辉云、曾丽斯、张美殷。血清48-lncRNA作为肝脏慢性疾病诊断标志物的应用。中国国家专利局，专利申请号： CN201610397094.X；申请日期：2015年06月08日；专利号：ZL 2016 1 0397094.X；授权日期：2020年6月16日；授权公告号：CN 107460234 B。
7） 王辉云、买世娟、王梦鹤、袁林静、李品东。AGPAT9基因在制备治疗肝癌药物、诊断及预后评估试剂中的应用。中国国家专利局，申请日期：2015年12月30日；专利号：ZL 2015 1 1033481.7；授权公告号：CN 105582536 B；授权日期：2019年12月10日。
8） 王辉云。鼻咽癌EB病毒血清抗体标签检测蛋白芯片及其试剂盒。中国国家专利局，专利申请号：201510800164.7；申请日期：2015年11月20日。
9） 王辉云、胡婧晔、康毅滨。一种用于乳腺癌预后判断的试剂盒。中国国家专利局，专利申请号：CN201410572963.9；申请日期：2014年10月23日；专利号：ZL 2014 1 0572963.9
10） 王辉云、黄国良、张美殷。CCDC158基因在制备肝癌治疗或诊断药物中的应用。国家专利局，专利申请号：CN201310168835.3 ，2012年5月10日。
学术成就和成果奖
1) 2016年，《肝癌多学科治疗策略优化的研究与应用》 获广东省科学技术一等奖
2) 2016年，《肝癌多学科治疗策略优化的研究与应用》获教育部科技进步二等奖
3) 2003年，获美国新泽西州州长和新泽西癌症研究委员会授予《新泽西癌症研究科学优秀奖》
4) 1999年，获中山医科大学肿瘤防治中心和北京天衡时代科技集团联合颁发《第一届天衡杯肿瘤科研奖 – 科技之星二等奖》。
5) 1996年，《甘草甜素等预防肝癌前病变发生的实验研究》获广东省医药卫生科技进步三等奖。
6) 1995年，获卫生部国际交流处和日本第一制药厂联合颁发《国际优秀博士生医药学奖》 。
7) 1992年，《大鼠鼻咽癌发病过程中血硒和谷胱甘酞过氧化酶的变化》一文在中山医科大学第六届中青年学术论坛获《优秀论文二等奖》。
8) 1991年，《鼻咽癌前病变和癌的化学预防与治疗的实验研究》获广东省科学技术进步三等奖。
9) 1991年，《鼻咽癌前病变和癌的化学预防与治疗的实验研究》获广东省医药卫生科技进步二等奖。
学术任职：
2018年《广东省精准医学会-免疫治疗学分会》 副主委
2007年―2012：《癌症》杂志编委
2010年－2018：《中华肿瘤防治杂志》编委
2010年－2018：《国际肿瘤学杂志》编委
学术专著：
1) 王辉云、黄龙。《生物芯片在肿瘤个体化医学中的应用》(3.37万字)。见: 黄文林主编《肿瘤个体化医学》第一版第十三章，人民卫生出版社，北京，2013年1月24日。ISBN: 978-7-117-16476-4/R·16477.
2) Li, H, Wang, H-Y,Cui, X., Luo, M., Hu, G., Greenawalt, D. M., Tereshchenko, I. V., Li, J. Y., Chu, Y., and Gao, R.. November 2007. High-throughput Genotyping of Single Nucleotide Polymorphisms with High Sensitivity. In Series: Methods in Molecular Biology Vol. 396, N. Bergman (ed.), Comparative Genomics Volume 2, Humana Press Inc., Totowa, New Jersey, USA, pp. 281-294. ISBN: 978-1-934115-37-4 (Print) 978-1-59745-515-2 (Online).
3) Li, H., Cui, X., Greenawalt, D. M., Hu, G., Chimge, N. O., Pramanik, S., Luo, M., Wang, H-Y, Tereshchenko, I. V., Azaro, M. A., Lin, Y., Yang, Q., Li, J. Y., Chu, Y., Lin, Z., Gao, R., Shen, L., Decoste, C. J., and Shih, W. J. September 2006. Microarray Analysis of a Large Number of Single-Nucleotide Polymorphisms in Individual Human Spermatozoa. In: Genetics of Male Infertility, D. T. Carrell (ed.), Humana Press Inc., Totowa, New Jersey, USA, page 55-76. ISBN: 978-1-58829-863-8.
发表的主要学术论文 (# 通讯或共同通讯作者）
1) Wang RQ, Long XR, Ge CL, Zhang MY, Huang L, Zhou NN, Hu Y, Li RL, Li Z, Chen DN, Zhang LJ, Wen ZS, Mai SJ, Wang HY #. Identification of a 4-lncRNA signature predicting prognosis of patients with non-small cell lung cancer: a multicenter study in China. J Transl Med. 2020 Aug 20;18(1):320.
2) Ji Liu, Rui Xu, Shi-Juan Mai, Yu-Shui Ma, Mei-Yin Zhang, Ping-Sheng Cao, Nuo-Qing Weng, Rui-Qi, Wang, Di Cao, Wei Wei, Rong-Ping Guo, Yao-Jun Zhang4, Li Xu4, Min-Shan Chen, Hui-Zhong Zhang, Long Huang, Da Fu and Hui-Yun Wang #. LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling. Theranostics, 2020; 10(17): 7527-7544.
3) Di Cao, Meng-Ke Chen, Qing-Feng Zhang, Yu-Feng Zhou, Mei-Yin Zhang, Shi-Juan Mai, Yao-Jun Zhang, Min-Shan Chen, Xiao-Xing Li, Hui-Yun Wang #. Identification of Immunological Subtypes of Hepatocellular Carcinoma With Expression Profiling of Immune-Modulating Genes. Aging (Albany NY), 2020 Jun 16;12. doi: 10.18632/aging.103395. Online ahead of print.
4) Weng NQ, Chi J, Wen J, Mai SJ, Zhang MY, Huang L, Liu J, Yang XZ, Xu GL, Fu JH, Wang HY #. The prognostic value of a seven-lncRNA signature in patients with esophageal squamous cell carcinoma: a lncRNA expression analysis. J Transl Med. 2020 Jan 31;18(1):47.
5) Wang R, Xu XY, Zhu H, Liang X, Li X, Jia MX, Wang QH, Wang HY #, Li XX, Zhao GJ. Androgen Receptor Promotes Gastric Carcinogenesis via Upregulating Cell Cycle-Related Kinase Expression. J Cancer. 2019 Jul 10;10(18):4178-4188.
6) Zeng JD, Wu WKK, Wang HY #, Li XX. Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer. Pharmacol Res. 2019 Jul 16: 104352.
7) Zhao XG, Hu JY, Tang J, Yi W, Zhang MY, Deng R, Mai SJ, Weng NQ, Wang RQ, Liu J, Zhang HZ, He JH, Wang HY #. miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer. Cell Death Dis. 2019 Jun 17;10(7):479
8) Wen W, Mai SJ, Lin HX, Zhang MY, Huang JL, Hua X, Lin C, Long ZQ, Lu ZJ, Sun XQ, Liu SL, Yang Q, Zhu Q, Wang HY #, Guo L. Identification of two microRNA signatures in whole blood as novel biomarkers for diagnosis of nasopharyngeal carcinoma. J Transl Med. 2019 Jun 3;17(1):186.
9) Chao Jiang, Rui Xu, Xiao-Xing Li,Yu-Feng Zhou, Xiao-Yi Xu,Yang Yang, Hui-Yun Wang #, X.F. Steven Zheng. Sorafenib and Carfilzomib Synergistically Inhibit the Proliferation, Survival, and Metastasis of Hepatocellular Carcinoma. Mol Cancer Ther; 2018 Dec;17(12):2610-2621.
10) Ju-deng Zeng, Ning Zhang, Gui-jun Zhao, Li-xia Xu, Yang Yang, Xiao-yi Xu, Meng-ke Chen, Hui-yun Wang* #, Steven XF Zheng, and Xiao-xing Li. MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma. J Cancer. 2018; 9(16): 2807–2816.
11) Lu Shi, Ruowen Xiao, Menghe Wang, Meiyin Zhang, Nuoqing Weng, Xinge Zhao, X.F. Steven Zheng, Huiyun Wang # and Shijuan Mai. MicroRNA‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42. Oncology Reports.2018;40: 2750-2757.
12) Zhang H, Li X, Yang Y, Zhang Y, Wang HY #, Zheng XFS. Significance and Mechanism of Androgen Receptor (AR) Overexpression and AR-mTOR Crosstalk in Hepatocellular Carcinoma. Hepatology. 2018 Jun; 67(6):2271-2286.
13) Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018 May 3;70(3):502-515.e8.
14) Huiping Li, Jiang Liu, Jianing Chen, Huiyun Wang (co-first author), Linbin Yang, Fei Chen, Siting Fan, Jing Wang, Bin Shao, Dong Yin, Musheng Zeng, Mengfeng Li, Jun Li, Fengxi Su, Qiang Liu, Herui Yao, Shicheng Su, Erwei Song. A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients. Nature Communication, 2018 Apr 24;9(1):1614.
15) Wang MH, Sun R, Zhou XM, Zhang MY, Lu JB, Yang Y, Zeng LS, Yang XZ, Shi L, Xiao RW, Wang HY #, Mai SJ. Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway. Cell Death Dis. 2018 Jan 5;9(1):2
16) Wang ZQ, Zhang MY, Deng ML, Weng NQ, Wang HY #, Wu SX. Low serum level of miR-485-3p predicts poor survival in patients with glioblastoma. PLoS One. 2017 Sep 20;12(9):e0184969
17) Jiang C, Xu R, Li XX, Wang YY, Liang WQ, Zeng JD, Zhang SS, Xu XY, Yang Y, Zhang MY, Wang HY #, Zheng XFS. p53R2 overexpression in cervical cancer promotes AKT signaling and EMT, and is correlated with tumor progression, metastasis and poor prognosis. Cell Cycle. 2017 Sep 17;16(18):1673-1682
18) Long XR, Zhang YJ, Zhang MY, Chen K, Zheng XF Steven, Wang HY #. Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases. Aging (Albany NY). 2017 Jun 27; 9(6):1565-1584.
19) Meng-He Wang, Xiao-Min Zhou, Mei-Yin Zhang, Lu Shi, Ruo-Wen Xiao, Li-Si Zeng, Xian-Zi Yang, X.F. Steven Zheng, Hui-Yun Wang # and Shi-Juan Mai. BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway. Aging (Albany NY). 2017 Apr; 9(4):1326-1340.
20) Pu HY, Xu R, Zhang MY, Yuan LJ, Hu JY, Huang GL, Wang HY #. Identification of microRNA-615-3p as a novel tumor suppressor in non-small cell lung cancer. Oncol Lett. 2017 Apr;13(4):2403-2410
21) Yang XZ, Cui SZ, Zeng LS, Cheng TT, Li XX, Chi J, Wang R, Zheng XF, Wang HY #. Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer. Aging (Albany NY). 2017 Mar 18;9(3):914-931. doi: 10.18632/aging.101200.
22) Xiao-Feng Xie, Qing Yang, Jun Chi, Xian-Zi Yang, Hui-Yun Wang #, Guo -Liang Xu. Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study. Chin J Cancer, 2017, 36(1):15
23) Cheng-Zuo Xiao, Wei Wei, Zhi-Xing Guo, Mei-Yin Zhang, Yong-Fa Zhang, Jia-Hong Wang, Ming Shi, Hui-Yun Wang #, Rong-Ping Guo. MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression. J Cancer Res Clin Oncol, 2017, 143(2): 263~273.
24) Jun Chi, Qing Yang, Xiao-Feng Xie, Xian-Zi Yang, Mei-Yin Zhang, Hui-Yun Wang #, Guo-Liang Xu. Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma. Aging, 2016 Sep 28; 8(9): 2204-2221.
25) Li-Si Zeng, Xian-Zi Yang, Yue-Feng Wen, Shi-Juan Mai, Meng-He Wang, Mei-Yin Zhang, X.F. Steven Zheng, Hui-Yun Wang #. Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma. Aging, 2016, May 31; 8(6):1236-49.
26) Ren Wang, Chen Yin, Xiao-Xing Li, Xian-Zi Yang, Yang Yang, Mei-Yin Zhang, Hui-Yun Wang #, and X.F. Steven Zheng. Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. Aging, 2016, May 23; 8(6):1184-200. （IF: 3.979）
27) Yue Li, Chi Kwan Tsang, Suihai Wang, Xiao‐Xing Li, Yang Yang, Liwu Fu, Wenlin Huang, Ming Li, Hui-Yun Wang #, X.F. Steven Zheng. MAF1 suppresses AKT‐mTOR signaling and liver cancer through activation of PTEN transcription. Hepatology. 2016, 31 March;63(6):1928-42.
28) Wei R, Cao L, Pu H, Wang HW, Zheng Y, Niu X, Weng X, Zhang H, Favus M, Zhang LJ, Jia W, Zeng YX, Amos CI, Lu S, Wang HY #, Liu Y, Liu W. TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer. Clin Cancer Res. 2015 Nov 15;21(22):5173-80 （IF: 8.722）
29) Zhang JL, Wang HY (co-first), Yang Q, Lin SY, Luo GY, Zhang R, Xu GL. Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer. World J Gastroenterol. 2015 Apr 14;21(14):4240-7.
30) Mei-Yin Zhang, Shu-Hong Li, Guo-Liang Huang, Guo-He Lin, Ze-Yu Shuang1, Xiang-Ming Lao, Li Xu, Xiao-Jun Lin, Hui-Yun Wang #, Sheng-Ping Li. Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis. BMC Cancer, 2015 Feb 18; 15:64.
31) Yin-Lian Cha, Pin-Dong Li, Lin-Jing Yuan, Mei-Yin Zhang, Yao-Jun Zhang, Hui-Lan Rao, Hui-Zhong Zhang, X.F. Steven Zheng, Hui-Yun Wang #,. EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma. PLoS One. 2015 Feb 6, 10(2): e0117493.
32) Janice D. Thomas, Yanjie Zhang, Yuehua Wei, Jun-Hung Cho, Laura E. Morris, Hui-Yun Wang, X. F. Steven Zheng. Rab1A Is a Novel Activator of mTORC1 Signaling and A Colorectal Oncogene. Cancer Cell, 2014 Oct 23, 26(5):754-769.
33) Zheng HQ, Sheng MH, Cha YL, Li WY, Blanco MA, Ren GG, Zhou TH, Storz P, Wang HY, Kang YB. PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell, 2014 Sep 8;26(3):358-73.
34) Peng HS, Liao MB, Zhang MY, Xie Y, Xu L, Zhang YJ, Zheng XF, Wang HY #, Chen YF. Synergistic inhibitory effect of hyperbaric oxygen combined with sorafenib on hepatoma cells. PLoS One. 2014 Jun 23; 9(6):e100814.
35) He L, Wang HY #, Zhang L, Huang L, Li JD, Xiong Y, Zhang MY, Jia WH, Yun JP, Luo RZ, Zheng M. Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer. Cell Death Dis. 2014 May 1; 5:e1205.
36) Xie Y, Wei RR, Huang GL, Zhang MY, Yuan YF, Wang HY #. Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma. Med Oncol. 2014 Mar; 31(3):844. Epub 2014 Jan 25.
37) Zhang JX, Song W, Chen ZH, Wei JH, Liao YJ, Lei J, Hu M, Chen GZ, Liao B, Lu J, Zhao HW, Chen W, He YL, Wang HY, Xie D, Luo JH. Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol. 2013 Dec;14(13):1295-306. [Epub 2013 Nov 12.]
38) Yang Q, Luo GY, Li Y, Shan HB, Wang HY #, Xu GL. Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma. Med Oncol. 2013 Dec;30(4):689.
39) Wei R, Huang GL, Zhang MY, Li BK, Zhang HZ, Shi M, Chen XQ, Huang L, Zhou QM, Jia WH, Zheng XF, Yuan YF, Wang HY #.Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma. Clin Cancer Res, 2013 Sep 1;19(17):4780-4791.
40) Yang S, Wang H, Guo Y, Chen S, Zhang MY, Shen J, Yu H, Miao J, Wang HY #, Wei W. RMP Plays Distinct Roles in the Proliferation of Hepatocellular Carcinoma Cells and Normal Hepatic Cells. Int J Biol Sci. 2013 Jul 5;9(6):637-48.
41) Liu N, Cui RX, He QM, Huang BJ, Sun Y, Xie D, Zeng J, Wang HY #, Ma J. Reduced expression of Dicer11 is associated with poor prognosis in patients with nasopharyngeal carcinoma. Med Oncol. 2013 Mar; 30(1):360.
42) Li PD, Zhang WJ, Zhang MY, Yuan LJ, Cha YL, Ying XF, Wu G, Wang HY #. Overexpression of RPS6KB1 predicts worse prognosis in primary HCC patients. Med Oncol. 2012 Dec;29(5):3070-6.
43) Rui-Xue Cui, Na Liu, Qing-Mei He, Wen-Fei Li, Bi-Jun Huang, Ying Sun, Ling-Long Tang, Mo Chen, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zeng, Ying Guo, Hui-Yun Wang #, Jun Ma. Low BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival. BMC Cancer, 2012 Aug 29;12(1):376.
44) Guo-Liang Huang, Bin-Kui Li, Mei-Yin Zhang, Rong-Rong Wei, Yun-Fei Yuan, Ming Shi, Xiao-Qian Chen, Long Huang, Hui-Zhong Zhang, Wanqing Liu, Bi-Jun Huang, Honghua Li, Xiao-Feng Zheng, Xian-Rong Luo, Hui-Yun Wang #. Allele loss and down-regulation of heparanase gene are associated with progression and poor prognosis of hepatocellular carcinoma. Plos One, 2012;7(8):e44061.
45) Na Liu, Nian-Yong Chen, Rui-Xue Cui, Wen-Fei Li, Yan Li, Rong-Rong Wei, Mei-Ying Zhang, Bi-Jun Huang, M.S., Ying Sun, Ling-Long Tang, Mo Chen, Guang-Qun Zhou, Qing-Mei He, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zen, Li-Zhi Liu, Li Li, Ying Guo, Hui-Yun Wang # and Jun Ma. Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncology, 2012, Jun; 13(6):633-41.
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更新日期：2020年9月1日
